INT245222

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.52
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 99.16 Very High Very High Very High
Inflammatory response 13 59.88 Quite High
rheumatoid arthritis 5 59.72 Quite High
tolerance 3 47.00 Quite Low
Arthritis 3 41.28 Quite Low
Multiple sclerosis 1 38.20 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.16 Very High Very High Very High
Systemic Lupus Erythematosus 56 94.64 High High
Atherosclerosis 39 92.80 High High
Neutropenia 1 86.20 High High
Paroxysmal Nocturnal Hemoglobinuria 1 80.40 Quite High
Disease 28 75.16 Quite High
Peripheral Arterial Disease 54 67.68 Quite High
Graft Vs Host Disease 1 65.92 Quite High
Rheumatoid Arthritis 5 59.72 Quite High
Nephritis 6 41.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data shown in this setting demonstrate that genes involved in TLR-mediated pathway are significantly up-regulated in intermediate or advanced lesions, including TLR1, TLR2, TLR7, and MyD88.
Regulation (regulated) of TLR7
1) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.82 Pain Relevance 0.11
Antimalarial drugs target TLR-7 and -9, and the development of a small oral molecule with similar actions has generated great interest from several companies (for example, ESAI (Woodcliff Lake, NJ, USA), Coley (Dusseldorff, Germany)/Xiphon (New Castle, Delaware, USA)/Pfizer (New York, NY, USA)).
Regulation (target) of TLR-7
2) Confidence 0.03 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 0.70 Pain Relevance 0.08

General Comments

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