INT245223

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 100.00 Very High Very High Very High
Inflammation 9 93.52 High High
Pain 1 91.84 High High
Inflammatory response 24 80.76 Quite High
tolerance 5 43.64 Quite Low
cytokine 11 15.96 Low Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 4 96.64 Very High Very High Very High
Disease 54 96.04 Very High Very High Very High
Fatigue 3 95.80 Very High Very High Very High
Fever 4 94.68 High High
INFLAMMATION 33 93.52 High High
Pain 2 91.84 High High
Peripheral Arterial Disease 54 88.56 High High
Herpes Simplex Virus 2 87.52 High High
Metastasis 44 86.80 High High
Skin Cancer 111 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the expression of TLR7, 8 and 10 was not detected in the current study, it is still possible that the expression of these genes and proteins can be induced in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of TLR7
1) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.45 Pain Relevance 0.18
Protein validation of TLR7 expression
Negative_regulation (validation) of Gene_expression (expression) of TLR7
2) Confidence 0.37 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.65 Pain Relevance 0.13
Intralesional interleukin-2 has also been given in combination with imiquimod, an agonist of toll-like receptor 7, with complete regression of 40.7% of 182 lesions treated, including cutaneous and subcutaneous lesions, and partial regression of 9.8%.63
Spec (partial) Negative_regulation (regression) of Gene_expression (agonist) of toll-like receptor 7 associated with agonist
3) Confidence 0.05 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004577 Disease Relevance 1.71 Pain Relevance 0.19

General Comments

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