INT245259

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.49
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
fibroblast 1
extracellular matrix 1
meibomian gland 1
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 127 100.00 Very High Very High Very High
Arthritis 103 99.88 Very High Very High Very High
Inflammation 101 99.84 Very High Very High Very High
rheumatoid arthritis 90 94.28 High High
Inflammatory mediators 2 80.32 Quite High
chemokine 9 78.16 Quite High
Bioavailability 1 77.04 Quite High
imagery 33 64.28 Quite High
cytokine 34 52.96 Quite High
fibrosis 39 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 106 99.88 Very High Very High Very High
INFLAMMATION 97 99.84 Very High Very High Very High
Fibrosis 51 99.84 Very High Very High Very High
Disorders Of The Lacrimal System 85 99.82 Very High Very High Very High
Cancer 278 97.04 Very High Very High Very High
Syndrome 2 96.00 Very High Very High Very High
Rheumatoid Arthritis 90 94.28 High High
Disease 52 91.36 High High
Adhesions 3 88.08 High High
Wound Healing 2 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Localization (implicated) of MMP-3 associated with fibrosis
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
MMP-3 is related to inflammation as well as cartilage and bone damage in CIA
Localization (related) of MMP-3 in cartilage associated with inflammation, metalloproteinase and arthritis
2) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.64 Pain Relevance 0.46
Three molecules that are vital to the pathophysiological extracellular matrix (ECM) structure, Tn-C, Tsp-1 and SL-1, are secreted by fibroblast-like cells and modulate the structural architecture of the tumor.
Localization (secreted) of SL-1 in fibroblast associated with cancer
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.08 Pain Relevance 0
-estradiol, in the meibomian gland include secreted acidic cysteine rich glycoprotein (regulates cell growth [71]), vascular endothelial growth factor A (promotes cell migration, among many other actions [71]), matrix metalloproteinase 3 (degrades fibronectin, laminin, gelatins and collagens [71]) and cathepsin K (degrades extracellular matrices [71]).
Localization (secreted) of matrix metalloproteinase 3 in meibomian gland associated with disorders of the lacrimal system and metalloproteinase
4) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.94 Pain Relevance 0.19
acted synergistically with IL-1 to stimulate IL-1RA production and inhibit MMP-3 and MMP-13 release in human chondrocytes [38,39].
Localization (release) of MMP-3 in chondrocytes associated with metalloproteinase
5) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.53 Pain Relevance 0.51
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Localization (secreted) of Mmp3 in extracellular matrix associated with metalloproteinase
6) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.42 Pain Relevance 0.11

General Comments

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