INT245262

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.87
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 12 99.48 Very High Very High Very High
fibrosis 101 98.98 Very High Very High Very High
metalloproteinase 4 86.72 High High
cytokine 43 75.68 Quite High
Inflammation 23 62.40 Quite High
agonist 1 58.56 Quite High
imagery 12 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
palliative 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 68 98.98 Very High Very High Very High
Cancer 644 98.00 Very High Very High Very High
Dna Damage 60 97.08 Very High Very High Very High
Lung Injury 7 91.20 High High
Apoptosis 160 88.72 High High
Death 19 81.84 Quite High
Hypopituitarism 11 77.28 Quite High
Adhesions 4 74.88 Quite High
INFLAMMATION 30 62.40 Quite High
Cataract 4 61.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of IFN/STAT1 pathway expression and definition of STAT1H and STAT1L genotype
Negative_regulation (/) of Gene_expression (expression) of STAT1
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.13 Pain Relevance 0
These cell lines showed negative IFN/STAT1 pathway expression scores ranging from ?
Negative_regulation (scores) of Gene_expression (expression) of STAT1
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.07 Pain Relevance 0
Finally, to provide mechanistic evidence of the dependence of STAT1 on the observed aggressive STAT1H genotype, we generated stable STAT1 knockdowns in the P2M5A cell line, which was the highest overexpressor of STAT1H in the P2 passage (Figure 3).
Negative_regulation (aggressive) of Gene_expression (genotype) of STAT1H associated with addiction
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.40 Pain Relevance 0.05
Previously, we showed that stable knockdown of STAT1 in IR-resistant and IFN?
Negative_regulation (knockdown) of Gene_expression (resistant) of STAT1
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
In the P1 cell lines, 3/8 (37.5%) of the cell lines exhibited a STAT1 expression score ?
Negative_regulation (exhibited) of Gene_expression (expression) of STAT1
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.11 Pain Relevance 0
Quantification of IFN/STAT1 pathway expression and definition of STAT1H and STAT1L genotype
Negative_regulation (Quantification) of Gene_expression (expression) of STAT1
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.13 Pain Relevance 0
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Negative_regulation (decreased) of Gene_expression (expression) of Stat1
7) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.25 Pain Relevance 0.11
In addition to studies showing that deletion of STAT-1 potentiates bleomycin-induced lung fibrosis in mice, other work demonstrated that aerosolized STAT-1 antisense oligodeoxynucleotides decreased the concentrations of TGF-?
Negative_regulation (decreased) of Gene_expression (oligodeoxynucleotides) of STAT-1 in lung associated with fibrosis and pulmonary fibrosis
8) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.56 Pain Relevance 0.26
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Negative_regulation (Measured) of Gene_expression (fractions) of STAT1
9) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0

General Comments

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