INT245263

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.84
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
4T1 8
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2 69.28 Quite High
cytokine 24 55.32 Quite High
Inflammation 41 49.84 Quite Low
chemokine 19 41.36 Quite Low
metalloproteinase 12 27.96 Quite Low
imagery 48 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 19 96.88 Very High Very High Very High
Diabetes Mellitus 154 88.08 High High
Systemic Lupus Erythematosus 2 86.16 High High
Hypoxia 8 80.32 Quite High
Stress 8 57.04 Quite High
Diabetes Mellitus-type I 7 52.00 Quite High
Cancer 297 50.08 Quite High
INFLAMMATION 47 49.84 Quite Low
Disorder Of Lipid Metabolism 1 28.96 Quite Low
Apoptosis 8 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic-derived factor (PANDER)-induced down-regulation of CDKN1A (cyclin-dependent kinase inhibitor 1A (P21)) expression coupled with induced CASP3-activation may serve a central role in islet cell death [132].
Negative_regulation (regulation) of Gene_expression (expression) of CDKN1A associated with death
1) Confidence 0.25 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.69 Pain Relevance 0.03
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Negative_regulation (reduced) of Gene_expression (levels) of Cdkn1a in 4T1
2) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.31 Pain Relevance 0.03
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Negative_regulation (displayed) of Gene_expression (levels) of p21 in 4T1
3) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.26 Pain Relevance 0.03
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Negative_regulation (displayed) of Gene_expression (levels) of Cdkn1a in 4T1
4) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.31 Pain Relevance 0.03
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Negative_regulation (reduced) of Gene_expression (levels) of p21 in 4T1
5) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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