INT24529

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal, Ins1) cytoplasm (Gal, Ins1) extracellular space (Ins1)
Golgi apparatus (Gal) carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
nerves 2
Gal (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 6 100.00 Very High Very High Very High
tetrodotoxin 2 81.12 Quite High
Clonidine 2 25.00 Low Low
agonist 1 25.00 Low Low
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 1 95.12 Very High Very High Very High
Bordatella Infection 3 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of galanin and somatostatin on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration [( Ca2+]i) were investigated using beta-cells isolated from obese hyperglycemic mice.
galanin Spec (investigated) Regulation (effects) of Localization (release) of insulin associated with obesity and somatostatin
1) Confidence 0.23 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2463254 Disease Relevance 0.10 Pain Relevance 0.12
These data suggest that galanin may modulate caerulein-stimulated amylase secretion by acting on cholinergic nerves and/or islet cells possibly via GALR2 to regulate insulin release.
galanin Spec (possibly) Regulation (regulate) of Localization (release) of insulin in nerves
2) Confidence 0.02 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19497960 Disease Relevance 0 Pain Relevance 0.13

General Comments

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