INT245298

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
4T1 1
fibroblast 1
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 11 95.00 High High
cytokine 8 74.88 Quite High
chemokine 4 74.00 Quite High
palliative 1 43.36 Quite Low
imagery 13 34.96 Quite Low
cINOD 16 31.04 Quite Low
agonist 1 9.16 Low Low
metalloproteinase 3 6.72 Low Low
Inflammatory response 2 5.52 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 99.68 Very High Very High Very High
Apoptosis 18 99.44 Very High Very High Very High
Hepatocellular Cancer 8 97.76 Very High Very High Very High
Reprotox - General 1 54 97.52 Very High Very High Very High
Stress 3 94.84 High High
Cancer 141 90.96 High High
Toxicity 9 83.24 Quite High
Prostatic Intraepithelial Neoplasia 14 71.12 Quite High
Benign Prostatic Hypertrophy 14 70.80 Quite High
Colon Cancer 39 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated expression of several genes known to be sensitive to hypoxia and/or glucose deprivation (Pfkfb3, Vegfc, Flt1 and Trib3), suggest that elevated expression of Gadd45 may be due to these factors and that 4T1 cells exist in a state of stress or pseudo-stress even under optimal culture conditions.


Negative_regulation (deprivation) of Vegfc in 4T1 associated with stress and hypoxia
1) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.58 Pain Relevance 0.07
Brivanib is a dual tyrosine kinase inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor.
Negative_regulation (inhibitor) of vascular endothelial growth factor in fibroblast
2) Confidence 0.22 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 1.10 Pain Relevance 0
Liu and colleagues (2000) reported suppressing vascular endothelial growth factor and inducing apoptosis in nude mouse xenografts of the human PC cell line (PC3) with three intraperitoneal injection of the COX-2 inhibitor NS398 (3 mg/kg) over 9 week.
Negative_regulation (suppressing) of vascular endothelial growth factor associated with cox-2 inhibitor, apoptosis and reprotox - general 1
3) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.98 Pain Relevance 0.08

General Comments

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