INT2453

Context Info Confidence 0.54 First Reported 1979 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 20 Total Number 21 Disease Relevance 3.49 Pain Relevance 4.08

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency plasma 3 cardiovascular system 2 PAG 1 smooth muscle 1 brain 1 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat noradrenaline 10 100.00 Clonidine 9 100.00 Potency 2 100.00 Intracerebroventricular 8 99.96 Action potential 2 99.64 Enkephalin 6 99.60 tetrodotoxin 2 99.44 anesthesia 9 98.70 Nicotine 2 98.32 Antinociceptive 3 98.26

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 27 100.00 Urological Neuroanatomy 8 99.26 Hypertension 11 99.10 Increased Venous Pressure Under Development 29 98.48 Wound Healing 2 92.48 Natriuresis 2 89.56 Cardiovascular Disease 21 86.80 Angina 2 86.32 Stress 18 85.36 Disorder Of Lipid Metabolism 8 84.48

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats.

Positive_regulation (increase) of AII in blood associated with pressure and volume under development and intracerebroventricular

1) Confidence 0.54 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3123970 Disease Relevance 0.18 Pain Relevance 0.05

Halothane (1.1% and 2.2% inspired) or fentanyl (50 and 200 micrograms/kg) anesthesia alone produced little change in basal plasma ANP levels but did increase plasma AII levels above unanesthetized baseline concentrations.

Positive_regulation (increase) of AII in plasma associated with anesthesia and halothane

2) Confidence 0.49 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2521280 Disease Relevance 0.26 Pain Relevance 0.62

We investigated the effects of previous central treatment with prazosin (an alpha 1-adrenoceptor antagonist) or clonidine (an alpha 2-adrenoceptor agonist) on the dipsogenic, pressor and tachycardic responses produced by intracerebroventricular (ICV) injection of angiotensin II (AII) in conscious rats.

Positive_regulation (injection) of AII associated with antagonist, agonist, intracerebroventricular and clonidine

3) Confidence 0.47 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2171000 Disease Relevance 0 Pain Relevance 0.45

These results strongly suggest that hypertension in fructose-treated rats is associated with increased in vitro vascular reactivity to AII and PE in the early stages of hypertension.

Positive_regulation (increased) of AII associated with hypertension

4) Confidence 0.41 Published 1996 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 8869002 Disease Relevance 0.35 Pain Relevance 0

Increases in perfusion pressure to clonidine, phenylephrine, noradrenaline (NA) and angiotensin II (AII) were observed in rat isolated tail arteries, and to NA in the isolated mesenteric vasculature from steroid and vehicle-treated rats.

Positive_regulation (Increases) of AII in vasculature associated with noradrenaline and clonidine

5) Confidence 0.40 Published 1988 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2907011 Disease Relevance 0.07 Pain Relevance 0.44

Angiotensin (AII) is associated with increased vascular smooth muscle growth and we have found increased levels of tissue AII during healing of wounded skin.

Positive_regulation (increased) of AII in smooth muscle

6) Confidence 0.38 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1530605 Disease Relevance 0.17 Pain Relevance 0.08

Observations made in this study revealed an increase in AII immunoreactivity (AII-ir) in both CSF and brain as well as an increase in the cerebral content of AI-ir in rats rendered tolerant to EA.

Positive_regulation (increase) of AII in brain associated with electroacupuncture

7) Confidence 0.36 Published 1990 Journal Sci. China, Ser. B, Chem. Life Sci. Earth Sci. Section Abstract Doc Link 2204346 Disease Relevance 0 Pain Relevance 0.44

Systemic administration of angiotensin II (AII) to the rat has previously been shown to induce a dose-dependent, hypothermic response manifested by a fall in colonic temperature (CT), a decrease in heat production and an increase in tail skin temperature (TST).

Positive_regulation (administration) of AII in tail skin

8) Confidence 0.35 Published 1985 Journal Peptides Section Abstract Doc Link 4070024 Disease Relevance 0.15 Pain Relevance 0.04

Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.

Positive_regulation (Activation) of AII

9) Confidence 0.31 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0 Pain Relevance 0

The effects of propranolol on angiotensin II (AII) enhancement of sympathetic nerve transmission were investigated in the in situ blood-perfused mesenteric vascular bed of the rat.

Positive_regulation (enhancement) of AII in nerve

10) Confidence 0.28 Published 1981 Journal Hypertension Section Abstract Doc Link 6259059 Disease Relevance 0 Pain Relevance 0

Tetrodotoxin (10(-7) g/ml) also blocked AII stimulation of VP release.

Positive_regulation (stimulation) of AII associated with tetrodotoxin

11) Confidence 0.25 Published 1979 Journal Endocrinology Section Abstract Doc Link 446341 Disease Relevance 0 Pain Relevance 0.24

These findings suggest that action potentials are generated in response to AII stimulation of specific receptors in the HNS and are requisite for VP release in response to this stimulus.

Positive_regulation (response) of AII associated with action potential

12) Confidence 0.25 Published 1979 Journal Endocrinology Section Abstract Doc Link 446341 Disease Relevance 0 Pain Relevance 0.24

These studies suggest that the central effect of AII stimulation on ACTH release in vivo could be, at least in part, through the release of hypothalamic CRF into the portal circulation.

Positive_regulation (stimulation) of AII

13) Confidence 0.17 Published 1986 Journal Endocrinology Section Abstract Doc Link 3015575 Disease Relevance 0 Pain Relevance 0.05

AII infusion resulted in a significant elevation in mean arterial pressure and in plasma AII and noradrenaline levels.

Positive_regulation (elevation) of AII in plasma associated with noradrenaline

14) Confidence 0.17 Published 1997 Journal J. Vasc. Res. Section Abstract Doc Link 9256089 Disease Relevance 0.07 Pain Relevance 0.13

This study shows for the first time the antinociceptive effect of RS, AI, AII and III in well-defined PAG regions, an effect that is receptor mediated for AII.

Positive_regulation (mediated) of AII in PAG associated with urological neuroanatomy and antinociceptive

15) Confidence 0.16 Published 2003 Journal Brain Res. Section Abstract Doc Link 12711094 Disease Relevance 0.60 Pain Relevance 0.58

AII infusion resulted in a significant elevation in mean arterial pressure and in plasma AII and noradrenaline levels.

Positive_regulation (resulted) of AII in plasma associated with noradrenaline

16) Confidence 0.12 Published 1997 Journal J. Vasc. Res. Section Abstract Doc Link 9256089 Disease Relevance 0.07 Pain Relevance 0.13

The present studies were designed to test, using a combination of in vivo and in vitro paradigms, the potency of angiotensin II (AII) to release ACTH, in relation to that of other neural peptides with corticotropin-releasing activity (CRA), such as synthetic corticotropin releasing factor (CRF), arginine vasopressin (AVP) and oxytocin (OXY); and to determine whether a central or peripheral locus is the primary site of action of the peptide.

Positive_regulation (potency) of AII in neural associated with potency

17) Confidence 0.10 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6318148 Disease Relevance 0 Pain Relevance 0.09

The effect of leucine5 -enkephalin on angiotensin II (AII)-stimulated release of oxytocin and vasopressin (VP) was investigated in the conscious male rat.

Spec (investigated) Positive_regulation (-stimulated) of AII associated with enkephalin

18) Confidence 0.09 Published 1984 Journal Brain Res. Section Abstract Doc Link 6722545 Disease Relevance 0 Pain Relevance 0.28

RESULTS: The HDL-cholesterol, apoA-I and apoA-II levels were all lower (P < 0.01 for each) in patients with variant angina and patients with stable effort angina as compared with control subjects.

Positive_regulation (lower) of apoA-II

19) Confidence 0.04 Published 1998 Journal Cardiovasc. Res. Section Body Doc Link 9659457 Disease Relevance 0.17 Pain Relevance 0

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

Positive_regulation (activity) of AII in cardiovascular system associated with increased venous pressure under development

20) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.54 Pain Relevance 0.09

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