INT245336

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DCD)
Anatomy Link Frequency
muscle 1
DCD (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 99.38 Very High Very High Very High
antagonist 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Cannabinoid 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 113 100.00 Very High Very High Very High
Cancer 56 100.00 Very High Very High Very High
Pancreatic Cancer 3 99.24 Very High Very High Very High
Stomach Cancer 13 98.34 Very High Very High Very High
Apoptosis 2 82.24 Quite High
Disease 4 73.68 Quite High
Acute Disease 1 59.12 Quite High
Weight Loss 7 51.08 Quite High
Syndrome 4 44.72 Quite Low
Congenital Anomalies 11 33.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data provide evidence indicating that the ATR ameliorates the symptoms of gastric cancer cachexia, most likely through mediation of cytokine production, and inhibition of PIF proteolysis.
Protein_catabolism (proteolysis) of PIF associated with appetite loss, stomach cancer and cytokine
1) Confidence 0.52 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529387 Disease Relevance 0.89 Pain Relevance 0.13
A tumor product, PIF is produced by cachexia-inducing murine and human tumors and initiates muscle protein degradation directly through activation of the proteasome pathway.
Protein_catabolism (degradation) of PIF in muscle associated with appetite loss and cancer
2) Confidence 0.31 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.87 Pain Relevance 0.03

General Comments

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