INT24536

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Context Info
Confidence 0.30
First Reported 1980
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 3.39
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal 4
neurons 4
hypothalamus 2
paw 2
nasal 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 265 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Morphine 14 99.72 Very High Very High Very High
qutenza 11 99.60 Very High Very High Very High
Central grey 10 99.60 Very High Very High Very High
dorsal root ganglion 63 99.40 Very High Very High Very High
transcutaneous nerve stimulation 90 99.36 Very High Very High Very High
Glutamate 3 99.32 Very High Very High Very High
Pain 24 99.26 Very High Very High Very High
Hyperalgesia 24 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 100.00 Very High Very High Very High
Urological Neuroanatomy 10 99.60 Very High Very High Very High
Pain 39 99.26 Very High Very High Very High
Ganglion Cysts 65 98.92 Very High Very High Very High
Hyperalgesia 27 98.78 Very High Very High Very High
INFLAMMATION 24 98.52 Very High Very High Very High
Pressure And Volume Under Development 16 97.80 Very High Very High Very High
Heart Rate Under Development 1 93.04 High High
Respiratory Distress 1 92.24 High High
Rhinitis 3 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the neurokinin-1 receptor localization results shown in Fig. 2A, we attempted to further quantify the levels of neurokinin-1 receptor in the cytosolic and membrane fractions of cultured DRG neurons.
Regulation (Based) of Localization (localization) of neurokinin-1 in neurons associated with dorsal root ganglion
1) Confidence 0.30 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.41 Pain Relevance 0.63
We examined the effect of opioids on the heat stimulus-evoked release of substance P (SP) into the subcutaneous space and the formation of edema in the rat hind paw.
Spec (examined) Regulation (effect) of Localization (release) of substance P in paw associated with pressure and volume under development, opioid and substance p
2) Confidence 0.16 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2463924 Disease Relevance 0.31 Pain Relevance 0.46
Consequently a project was designed to determine whether intranasal capsaicin pretreatment would affect nasal substance P release measured in nasal secretion.
Spec (whether) Regulation (affect) of Localization (release) of substance P in nasal associated with qutenza and substance p
3) Confidence 0.14 Published 1997 Journal Am J Rhinol Section Abstract Doc Link 9292182 Disease Relevance 0.54 Pain Relevance 1.05
Here we assessed whether changes in the spinal release of the nociceptive peptide substance P (SP) contributes to this effect.
Spec (whether) Regulation (changes) of Localization (release) of substance P in spinal associated with nociception and substance p
4) Confidence 0.10 Published 2001 Journal Neuroreport Section Abstract Doc Link 11201084 Disease Relevance 0.28 Pain Relevance 0.57
Intracerebral microdialysis was used to measure changes in the extracellular level of substance P (SP) released from the periaqueductal gray (PAG) and the preoptic anterior hypothalamus (POAH) of freely moving Sprague-Dawley rats after noxious cold stimulation.
Regulation (changes) of Localization (released) of substance P in hypothalamus associated with central grey and substance p
5) Confidence 0.04 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262375 Disease Relevance 0.43 Pain Relevance 0.61
The present study investigated the influences of paclitaxel and vinorelbine on the substance P (sP) release from cultured dorsal root ganglion (DRG) cells using a radioimmunoassay.
Spec (investigated) Regulation (influences) of Localization (release) of substance P in DRG associated with ganglion cysts, dorsal root ganglion and substance p
6) Confidence 0.04 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19376141 Disease Relevance 0.46 Pain Relevance 0.25
c-Src kinase activation regulates preprotachykinin gene expression and substance P secretion in rat sensory ganglia.
Regulation (regulates) of Localization (secretion) of substance P in ganglia associated with substance p
7) Confidence 0.04 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622206 Disease Relevance 0.09 Pain Relevance 0.43
The aim of the present study was to determine the optimal intensity and interval of repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia in a monoarthritic pain model of the rat, and to assess the changes of the spinal substance P (SP) release in response to TENS treatment.
Regulation (changes) of Localization (release) of substance P in spinal associated with pain, hyperalgesia, inflammation, transcutaneous nerve stimulation and substance p
8) Confidence 0.03 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC1810365 Disease Relevance 0.86 Pain Relevance 1.29
Multibarrelled microelectrodes were used to test the effects of iontophoretically released substance P (SP), morphine, glutamate, and naloxone on spinal cord dorsal horn neurons.
Regulation (effects) of Localization (released) of substance P in neurons associated with glutamate, narcan, dorsal horn neuron, spinal cord, morphine and substance p
9) Confidence 0.01 Published 1980 Journal Brain Res. Section Abstract Doc Link 6153556 Disease Relevance 0 Pain Relevance 1.14

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