INT245360

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.37
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rho) Golgi apparatus (Rho) plasma membrane (Rho)
signal transducer activity (Rho)
Anatomy Link Frequency
eye 2
Rho (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 1 91.36 High High
Pain 1 65.76 Quite High
agonist 3 50.64 Quite High
Catecholamine 1 42.56 Quite Low
Opioid 1 39.92 Quite Low
Central nervous system 8 10.60 Low Low
addiction 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 95.88 Very High Very High Very High
Pain 1 65.76 Quite High
Retina Disease 9 15.36 Low Low
Infection 5 5.00 Very Low Very Low Very Low
Retroviridae Infections 4 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Pheochromocytoma 2 5.00 Very Low Very Low Very Low
Muscular Dystrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The delay between photon absorption by rhodopsin and activation of the receptor current is only 20?
Positive_regulation (activation) of Gene_expression (absorption) of rhodopsin
1) Confidence 0.49 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0.07 Pain Relevance 0.11
Rhodopsin immunostaining on eye sections at PN33: Confirmatory experiments
Positive_regulation (experiments) of Gene_expression (immunostaining) of Rhodopsin in eye
2) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of rhodopsin
3) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Positive_regulation (overexpressing) of Gene_expression (-) of rhodopsin
4) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
The transition from inactive Meta I to Meta II further involves uptake of a solute proton by a cytoplasmic group,14 which renders the conformational equilibrium between Meta I and Meta II pH-dependent.15 These two protonation switches are coupled during rhodopsin activation and this coupling was shown to be mediated by certain groups of the all-trans retinal ligand, such as the 9-methyl group on the polyene and the ionone ring.16
Positive_regulation (during) of Gene_expression (activation) of rhodopsin
5) Confidence 0.11 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.03

General Comments

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