INT245515

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 5.07
Pain Relevance 6.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptors 4
salivary gland 4
embryos 1
neuronal 1
nerve 1
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 324 100.00 Very High Very High Very High
calcitonin gene related peptide 22 100.00 Very High Very High Very High
Neuropeptide 20 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
Neuropathic pain 159 97.40 Very High Very High Very High
Somatostatin 6 91.20 High High
trigeminal ganglion 152 89.84 High High
dorsal root ganglion 134 88.00 High High
allodynia 27 87.24 High High
Sciatic nerve 18 81.20 Quite High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 103 100.00 Very High Very High Very High
Hypersensitivity 24 98.72 Very High Very High Very High
Neuropathic Pain 190 97.40 Very High Very High Very High
Nervous System Injury 24 95.56 Very High Very High Very High
Repression 24 91.56 High High
Ganglion Cysts 310 89.84 High High
Toxicity 6 89.68 High High
Megacolon 18 89.04 High High
Nociception 48 88.92 High High
Targeted Disruption 207 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upstream signals and transcriptional regulation of RUNX genes have been studied in non-neuronal tissues [37].
Regulation (regulation) of RUNX in neuronal
1) Confidence 0.61 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.61 Pain Relevance 0.18
This interaction results in up-regulation of a Runx1a cDNA and subsequent IRES-EGFP expression.
Regulation (regulation) of Runx1a
2) Confidence 0.45 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.29 Pain Relevance 0.06
By analyzing how Runx1-persistent and Runx1-transient nociceptors were affected in various Runx1 mutant mice, we recognize several distinct modes of Runx1 activity in controlling nociceptor development.
Spec (analyzing) Regulation (affected) of Runx1 in nociceptors associated with nociceptor
3) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.10 Pain Relevance 0.95
By analyzing how Runx1-persistent and Runx1-transient nociceptors were affected in various Runx1 mutant mice, we recognize several distinct modes of Runx1 activity in controlling nociceptor development.
Spec (analyzing) Regulation (affected) of Runx1 in nociceptors associated with nociceptor
4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.11 Pain Relevance 0.96
By analyzing how Runx1-persistent and Runx1-transient nociceptors were affected in various Runx1 mutant mice, we recognize several distinct modes of Runx1 activity in controlling nociceptor development.
Spec (analyzing) Regulation (affected) of Runx1-persistent in nociceptors associated with nociceptor
5) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.11 Pain Relevance 0.97
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Runx1 associated with calcitonin gene related peptide, neuropeptide and substance p
6) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 1.09
Runx1 is initially co-expressed with TrkA in the nociceptor lineage [7,8], and initiation of TrkA expression is not dependent on Runx1 [48].
Neg (not) Regulation (dependent) of Runx1 in nociceptor associated with nociceptor
7) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.20 Pain Relevance 0.30
Te is the Ct cycle number of an interested gene such as Runx1 observed in a sample of salivary gland from the treated group, Tn is the Ct cycle number of the housekeeping genes GAPDH observed in the same sample while Ce is the average Ct cycle number of the same target gene such as Runx1 observed in a sample in the control group, Cn is the average Ct cycle number of housekeeping gene GAPDH in the same sample.
Regulation (cycle) of Runx1 in salivary gland
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0 Pain Relevance 0
Te is the Ct cycle number of an interested gene such as Runx1 observed in a sample of salivary gland from the treated group, Tn is the Ct cycle number of the housekeeping genes GAPDH observed in the same sample while Ce is the average Ct cycle number of the same target gene such as Runx1 observed in a sample in the control group, Cn is the average Ct cycle number of housekeeping gene GAPDH in the same sample.
Regulation (is) of Runx1 in salivary gland
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0 Pain Relevance 0
Te is the Ct cycle number of an interested gene such as Runx1 observed in a sample of salivary gland from the treated group, Tn is the Ct cycle number of the housekeeping genes GAPDH observed in the same sample while Ce is the average Ct cycle number of the same target gene such as Runx1 observed in a sample in the control group, Cn is the average Ct cycle number of housekeeping gene GAPDH in the same sample.
Regulation (average) of Runx1 in salivary gland
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0 Pain Relevance 0
Te is the Ct cycle number of an interested gene such as Runx1 observed in a sample of salivary gland from the treated group, Tn is the Ct cycle number of the housekeeping genes GAPDH observed in the same sample while Ce is the average Ct cycle number of the same target gene such as Runx1 observed in a sample in the control group, Cn is the average Ct cycle number of housekeeping gene GAPDH in the same sample.
Regulation (number) of Runx1 in salivary gland
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0 Pain Relevance 0
Runx1+ cells were detected in the LPBS in sections from Atoh1+/+ (Fig. 6A1–4) and Atoh1+/– (Fig. 6B1–4) littermates and there did not appear to be a difference in Runx1 immunoreactivity between those embryos.
Regulation (immunoreactivity) of Runx1 in embryos
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.19
These findings suggest that modulation of Runx1 activity with Runx1a or with Runx1 siRNA deserves further investigation as a potential treatment strategy for nerve injury-induced neuropathic pain.
Regulation (modulation) of Runx1 in nerve associated with nervous system injury and neuropathic pain
13) Confidence 0.27 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.05 Pain Relevance 0.76
These data suggest that Runx1a has a specific role in NCSC development and that modulation of Runx1a activity may reduce mechanical hypersensitivity associated with neuropathic pain.



Regulation (modulation) of Runx1a associated with hypersensitivity and neuropathic pain
14) Confidence 0.27 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853355 Disease Relevance 0.59 Pain Relevance 0.36
We chose to control Runx1 using the Sox10 pattern of expression, since Runx1 had been suggested to play a key role in the initial stage of differentiation of NCSCs into neurons [11].
Regulation (control) of Runx1 in neurons
15) Confidence 0.25 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.16 Pain Relevance 0.15
Interestingly, two putative target genes that are repressed by Runx1, trkA and CGRP, were unaffected in the delta446 mice [53].
Neg (unaffected) Regulation (unaffected) of Runx1
16) Confidence 0.20 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.65 Pain Relevance 0.15
Role of HCT in Elderly AML: Allogeneic Hematopoietic Cell Transplantation after Host-Adapted Conditioning
Regulation (Role) of AML associated with myeloid leukemia
17) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902223 Disease Relevance 0.65 Pain Relevance 0.06

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