INT245517

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 49
Total Number 50
Disease Relevance 17.70
Pain Relevance 12.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
neurons 17
sensory neurons 4
neurite 4
neuronal 4
embryos 2
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 530 99.92 Very High Very High Very High
midbrain 2 99.64 Very High Very High Very High
nociceptor 743 99.48 Very High Very High Very High
Neuropathic pain 356 99.44 Very High Very High Very High
dorsal root ganglion 755 98.76 Very High Very High Very High
Spinal cord 234 98.68 Very High Very High Very High
Inflammation 60 98.00 Very High Very High Very High
Peripheral nervous system 48 94.48 High High
withdrawal 108 94.16 High High
Neuropeptide 58 91.20 High High
Disease Link Frequency Relevance Heat
Repression 78 100.00 Very High Very High Very High
Ganglion Cysts 1365 99.92 Very High Very High Very High
Injury 184 99.72 Very High Very High Very High
Targeted Disruption 682 99.48 Very High Very High Very High
Neuropathic Pain 406 99.44 Very High Very High Very High
Hypersensitivity 76 99.20 Very High Very High Very High
INFLAMMATION 60 98.00 Very High Very High Very High
Neurodegenerative Disease 93 97.52 Very High Very High Very High
Megacolon 72 96.60 Very High Very High Very High
Nociception 291 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the neuropathic pain experiments we used three groups of double transgenic mice: 1) without injury as a control group, 2) with injury but without DOX-activated Runx1a expression as a second control group, and 3) with injury and with DOX-activated Runx1a expression.
Neg (without) Positive_regulation (activated) of Gene_expression (expression) of Runx1a associated with targeted disruption, injury and neuropathic pain
1) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.94 Pain Relevance 0.18
DOX-induced ectopic expression of Runx1a in Sox10-rtTA/TRE-Runx1a embryos results in retarded fetal growth, pigment defects, megacolon, and dystrophic DRGs
Positive_regulation (induced) of Gene_expression (expression) of Runx1a in embryos associated with megacolon
2) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.22 Pain Relevance 0.03
For the neuropathic pain experiments we used three groups of double transgenic mice: 1) without injury as a control group, 2) with injury but without DOX-activated Runx1a expression as a second control group, and 3) with injury and with DOX-activated Runx1a expression.
Neg (without) Positive_regulation (activated) of Gene_expression (expression) of Runx1a associated with targeted disruption, injury and neuropathic pain
3) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.96 Pain Relevance 0.18
Thus, NGF signalling is essential for sustained expression of Runx1.
Positive_regulation (essential) of Gene_expression (expression) of Runx1
4) Confidence 0.69 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.74 Pain Relevance 0.28
In the chick, it has been suggested that Runx1 directly activates TrkA transcription and that Runx1 overexpression in progenitors in vivo induces ectopic expression of TrkA [32].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx1
5) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.42 Pain Relevance 0.10
This, in conjunction with the strong upregulation of RET would suggest that both types of nonpeptidergic genes are controlled by the Runx1 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx1
6) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.05 Pain Relevance 0.13
The mechanism for this might be due to the specific targeting of Sox10-expressing cells for Runx1 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx1
7) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.06 Pain Relevance 0.13
This is in accordance with previous in vitro data on Runx1 overexpression in bNCSCs promoting survival and neuronal maturation but not neurogenesis per se [32].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx1 in neuronal associated with neurodegenerative disease
8) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.10 Pain Relevance 0.07
We next assessed how forced Runx1 expression influences the differentiation of bNCSCs in vitro.
Positive_regulation (forced) of Gene_expression (expression) of Runx1
9) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.09 Pain Relevance 0
In agreement with these findings, we found that DOX-induced Runx1 expression increased neurite outgrowth in bTUB+ cells in culture (Fig. 2A, 2B; quantified in c; p = 3.6 × 10?
Positive_regulation (increased) of Gene_expression (expression) of Runx1 in neurite
10) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.57 Pain Relevance 0.27
Compared with control transplants, we observed a significant increase in the number of TrkA+ cells as well as a reduction in the numbers of cells not expressing bTUB or GFAP in DOX-treated transplants, suggesting that Runx1 overexpression might be sufficient to drive initial differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx1
11) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.07 Pain Relevance 0.10
Our data show that exogenously induced Runx1 expression does not affect the relative neuron/glia proportion in the transplants.
Positive_regulation (induced) of Gene_expression (expression) of Runx1 in neuron
12) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.13
Furthermore, transfection of primitive murine or human hematopoietic cells with Runx1a markedly enhanced their engraftment potential compared to cells transfected with Runx1b (6).
Positive_regulation (transfected) of Gene_expression (transfected) of Runx1b in hematopoietic cells
13) Confidence 0.50 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0 Pain Relevance 0
For example, while most Runx1-persistent nociceptors, including TRPM8+ and Mrgprd+ neurons, are nonpeptidergic [26,28,29], about 15% of adult CGRP+ neurons also show detectable Runx1 expression (See Additional file 6).
Positive_regulation (show) of Gene_expression (expression) of Runx1 in neurons associated with nociceptor
14) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.38 Pain Relevance 1.31
For example, while most Runx1-persistent nociceptors, including TRPM8+ and Mrgprd+ neurons, are nonpeptidergic [26,28,29], about 15% of adult CGRP+ neurons also show detectable Runx1 expression (See Additional file 6).
Positive_regulation (detectable) of Gene_expression (expression) of Runx1 in neurons associated with nociceptor
15) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.38 Pain Relevance 1.31
Uncovering two Runx1-dependent differentiation programs necessary for inflammatory and neuropathic pain
Positive_regulation (Uncovering) of Gene_expression (Uncovering) of Runx1 associated with inflammation and neuropathic pain
16) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.30 Pain Relevance 1.06
Subsequently, the generation of specific antibodies against Runx1 and Runx3 and the utilization of Runx1?
Positive_regulation (generation) of Gene_expression (antibodies) of Runx1
17) Confidence 0.50 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.73 Pain Relevance 0.30
Earlier in situ hybridization studies indicated strong expression of Runx1 mRNA in spinal motor neurons, DRG, cranial ganglia and specialized sensory epithelial structures such as olfactory and gustatory mucosa, and follicles of the vibrissae [20].
Positive_regulation (indicated) of Gene_expression (expression) of Runx1 in olfactory associated with dorsal root ganglion
18) Confidence 0.50 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.91 Pain Relevance 0.24
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
Positive_regulation (induction) of Gene_expression (essential) of Runx1 in neurons associated with repression
19) Confidence 0.50 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.28
Using the Runx1-conditional knockout mouse, it was shown that Runx1 is dispensable for the de novo induction of TrkA [34].
Positive_regulation (induction) of Gene_expression (dispensable) of Runx1 associated with targeted disruption
20) Confidence 0.50 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.91 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox