INT245529

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.42
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
nerve 1
DRG 1
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 110 98.92 Very High Very High Very High
Neuropathic pain 90 95.08 Very High Very High Very High
Calcitonin gene-related peptide 5 91.48 High High
Neuropeptide 9 90.20 High High
allodynia 5 86.68 High High
Peripheral nerve injury 5 78.64 Quite High
Eae 25 74.16 Quite High
Peripheral nervous system 9 68.36 Quite High
withdrawal 35 65.36 Quite High
Sciatic nerve 20 47.88 Quite Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 58 100.00 Very High Very High Very High
Leukemia 22 98.96 Very High Very High Very High
Ganglion Cysts 116 98.92 Very High Very High Very High
Neurodegenerative Disease 23 98.76 Very High Very High Very High
Genetic Translocation 2 97.36 Very High Very High Very High
Nervous System Injury 10 95.92 Very High Very High Very High
Neuropathic Pain 95 95.08 Very High Very High Very High
Repression 21 89.40 High High
Apoptosis 14 83.48 Quite High
Embryonal Carcinoma 2 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The short Runx1 isoform (Runx1a) has a strong affinity for binding to the DNA consensus sequence which is common for all types of Runx proteins but lacks a transactivation domain.
Runx1a Binding (binding) of
1) Confidence 0.48 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.26 Pain Relevance 0.24
The short Runx1 isoform (Runx1a) has a strong affinity for binding to the DNA consensus sequence which is common for all types of Runx proteins but lacks a transactivation domain.
Runx1a Binding (affinity) of
2) Confidence 0.48 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.26 Pain Relevance 0.24
The short Runx1 isoform (Runx1a) has a strong affinity for binding to the DNA consensus sequence which is common for all types of Runx proteins but lacks a transactivation domain.
Runx1 Binding (affinity) of
3) Confidence 0.48 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.26 Pain Relevance 0.24
Both Runt and AML1 encode a DNA binding subunit of the heterodimeric transcription factor PEBP2/CBF.
AML1 Binding (binding) of
4) Confidence 0.37 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.49 Pain Relevance 0
The last discovery was particularly relevant to developmental neurobiology and, since then, several groups have characterized not only Runx3, but also Runx1 as a crucial regulator of DRG neurogenesis [18,19].
Runx1 Binding (characterized) of in DRG associated with dorsal root ganglion and neurodegenerative disease
5) Confidence 0.37 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.97 Pain Relevance 0.19
These findings suggest that modulation of Runx1 activity with Runx1a or with Runx1 siRNA deserves further investigation as a potential treatment strategy for nerve injury-induced neuropathic pain.
Runx1 Binding (activity) of in nerve associated with nervous system injury and neuropathic pain
6) Confidence 0.36 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.05 Pain Relevance 0.76
The short Runx1 isoform (Runx1a) has a strong affinity for binding to the DNA consensus sequence which is common for all types of Runx proteins but lacks a transactivation domain.
Runx1 Binding (binding) of
7) Confidence 0.36 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.26 Pain Relevance 0.24
While these miRNAs target AML1, this transcription factor binds and transcriptionally inhibits expression of miR-17-5p, miR-20a, and miR-106a in a mutual negative feedback loop [128].
AML1 Binding (binds) of
8) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.21 Pain Relevance 0
Nevertheless, because self-renewal is normally a unique feature of HSC and high levels of miR-29a expression are associated with HSC and AML, we hypothesize that miR-29a contributes to HSC and LSC self-renewal.
AML Binding (associated) of associated with myeloid leukemia
9) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.66 Pain Relevance 0

General Comments

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