INT245531

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
DRG 1
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 55 98.28 Very High Very High Very High
nociceptor 33 94.00 High High
trigeminal ganglion 76 59.84 Quite High
Central nervous system 4 44.96 Quite Low
Spinal cord 12 36.80 Quite Low
Peripheral nervous system 2 24.64 Low Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 10 98.94 Very High Very High Very High
Ganglion Cysts 143 98.28 Very High Very High Very High
Neurodegenerative Disease 7 98.12 Very High Very High Very High
Apoptosis 2 83.48 Quite High
Cancer 3 81.16 Quite High
Bone Cancer 1 65.20 Quite High
Leukemia 2 59.28 Quite High
Hematological Disease 2 57.56 Quite High
Embryonal Carcinoma 1 45.12 Quite Low
Myeloid Leukemia 1 33.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Runx3 repression of TrkB expression appears to be mediated by direct binding of Runx3 to the Ntrk2 locus [44].
Runx3 Binding (binding) of associated with repression
1) Confidence 0.46 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.21
The last discovery was particularly relevant to developmental neurobiology and, since then, several groups have characterized not only Runx3, but also Runx1 as a crucial regulator of DRG neurogenesis [18,19].
Runx3 Binding (characterized) of in DRG associated with dorsal root ganglion and neurodegenerative disease
2) Confidence 0.37 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.97 Pain Relevance 0.18

General Comments

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