INT245532

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.56
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 2
skin 2
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 4 98.60 Very High Very High Very High
Pain 30 97.96 Very High Very High Very High
unmyelinated 2 91.64 High High
Neuropeptide 2 91.20 High High
Spinal cord 11 90.72 High High
dorsal root ganglion 55 90.08 High High
Cancer pain 23 73.84 Quite High
nociceptor 5 72.00 Quite High
Nerve growth factor 25 70.12 Quite High
Analgesic 5 66.52 Quite High
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Pain 31 97.96 Very High Very High Very High
Ganglion Cysts 58 90.08 High High
Neuroma 25 88.72 High High
Nociception 15 80.56 Quite High
Targeted Disruption 17 75.44 Quite High
Bone Cancer 14 73.64 Quite High
Dermatitis 1 62.96 Quite High
INFLAMMATION 6 54.24 Quite High
Injury 5 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
Negative_regulation (repression) of Positive_regulation (induction) of trkA in neurons associated with repression
1) Confidence 0.34 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.65 Pain Relevance 0.28
Thus, since bone appears to lack the redundancy of the C-fiber non-peptidergic IB4/RET+ nerve fibers that are present in skin [10], blocking TrkA activation may be particularly efficacious in relieving bone pain vs. skin pain.


Negative_regulation (blocking) of Positive_regulation (activation) of TrkA in skin associated with pain and c fibre
2) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.91 Pain Relevance 1.06

General Comments

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