INT245535

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.03
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
embryos 1
sensory neurons 1
body 1
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 110 98.92 Very High Very High Very High
nociceptor 34 90.64 High High
trigeminal ganglion 77 80.48 Quite High
Dorsal horn 2 60.56 Quite High
Spinal cord 22 55.56 Quite High
Neuropeptide 8 28.52 Quite Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 201 98.92 Very High Very High Very High
Targeted Disruption 77 98.84 Very High Very High Very High
Nociception 27 71.96 Quite High
Starvation 2 68.20 Quite High
Death 6 67.48 Quite High
Sprains And Strains 4 64.96 Quite High
Repression 13 61.16 Quite High
Neurodegenerative Disease 11 52.16 Quite High
General Immunology 2 16.00 Low Low
Osteoporosis 2 8.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray studies have shown decreased levels of Runx1 and Runx3 transcripts in the sensory neurons of Brn-3a-knokout mice [40,41].
Transcription (levels) of Runx3 in sensory neurons
1) Confidence 0.71 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.17
In transgenic embryos expressing a Brn3a-VP16 dominant transactivator, Runx3 mRNA expression is increased, suggesting that it is a direct regulatory target of Brn3a.
Transcription (expression) of Runx3 in embryos associated with targeted disruption
2) Confidence 0.68 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 0.32
The mRNA expression and protein synthesis for Runx1/Runx3 are tightly regulated and DRG is one of the tissues in which Runx1/Runx3 display their highest protein levels among the entire body; how do DRG neurons achieve such a high protein level for Runx1/Runx3?
Transcription (expression) of Runx3 in body associated with dorsal root ganglion
3) Confidence 0.23 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.91 Pain Relevance 0.21

General Comments

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