INT245536

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.22
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
neurons 8
nociceptors 2
neurite 2
body 2
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 22 100.00 Very High Very High Very High
Neuropeptide 17 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
nociceptor 336 99.98 Very High Very High Very High
dorsal root ganglion 261 99.80 Very High Very High Very High
Spinal cord 64 98.36 Very High Very High Very High
trigeminal ganglion 153 91.92 High High
Somatostatin 6 91.20 High High
IPN 57 90.64 High High
Neuropathic pain 105 89.20 High High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 104 100.00 Very High Very High Very High
Ganglion Cysts 440 99.80 Very High Very High Very High
Targeted Disruption 195 99.70 Very High Very High Very High
Pruritus 3 98.92 Very High Very High Very High
Death 21 98.32 Very High Very High Very High
Nociception 78 96.00 Very High Very High Very High
Inflammatory Pain 57 90.64 High High
Neuropathic Pain 132 89.20 High High
Repression 23 86.08 High High
Pain 66 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maturation of these sensory subtypes is known to depend on the expression of Runx transcription factors.
Regulation (depend) of Gene_expression (expression) of Runx
1) Confidence 0.58 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.59 Pain Relevance 0.33
Our results demonstrate that using the Tet-system to exogenously control Runx1 expression in grafted bNCSCs resulted in their long-term survival, increased neurite outgrowth, and selective differentiation of the neuronal population toward a nonpeptidergic nociceptive neuronal phenotype.
Regulation (control) of Gene_expression (expression) of Runx1 in neurite associated with nociception
2) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.19 Pain Relevance 0.07
Notably, dividing nociceptors based on Runx1 expression does not follow the classic subdivision of nociceptors, namely CGRP+ peptidergic nociceptors versus IB4+ non-peptidergic nociceptors [1,23].
Regulation (based) of Gene_expression (expression) of Runx1 in nociceptors associated with nociceptor
3) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.58 Pain Relevance 1.32
Mrgpra3+ neurons have been implicated in transmitting itch evoked by chloroquine [30], and these neurons do not show persistent Runx1 expression [24].
Neg (not) Regulation (show) of Gene_expression (expression) of Runx1 in neurons associated with pruritus
4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.10 Pain Relevance 0.06
In Ngf-Bax compound knockout DRG, TrkA neurons are hypotrophic although de novo Runx1 expression is unaffected [42].
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of Runx1 in neurons associated with targeted disruption and dorsal root ganglion
5) Confidence 0.45 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.22
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Gene_expression (expression) of Runx1 associated with calcitonin gene related peptide, neuropeptide and substance p
6) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 1.11
Differentiation of Sox10+/rtTA:TREBi-Runx1-EYFP bNCSCs In Vitro
Regulation (Differentiation) of Gene_expression (bNCSCs) of Runx1
7) Confidence 0.41 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.09 Pain Relevance 0
In the same study, siRNA knock-down of early Runx1 expression as well as overexpression of a general dominant-negative Runx protein was shown to down-regulate TrkA expression and cause the subsequent death of the neurons.
Regulation (regulate) of Gene_expression (expression) of Runx1 in neurons associated with targeted disruption and death
8) Confidence 0.41 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.61 Pain Relevance 0.17
Our data show that exogenously induced Runx1 expression does not affect the relative neuron/glia proportion in the transplants.
Neg (not) Regulation (affect) of Gene_expression (expression) of Runx1 in neuron
9) Confidence 0.41 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.13
In this mouse line, Runx1 expression is under the control of the panneuronal Tau promoter but is not activated until the 'STOP' cassette is removed through Cre-mediated recombination.
Regulation (under) of Gene_expression (expression) of Runx1
10) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.68 Pain Relevance 0.92
However, Runx1 expression is not maintained to the neonate stage and the expression of all putative Runx1 target genes is altered [42].
Regulation (altered) of Gene_expression (expression) of Runx1
11) Confidence 0.27 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.68 Pain Relevance 0.25
The mRNA expression and protein synthesis for Runx1/Runx3 are tightly regulated and DRG is one of the tissues in which Runx1/Runx3 display their highest protein levels among the entire body; how do DRG neurons achieve such a high protein level for Runx1/Runx3?
Regulation (regulated) of Gene_expression (synthesis) of Runx1 in body associated with dorsal root ganglion
12) Confidence 0.27 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.91 Pain Relevance 0.21
The intensive chemotherapy regime that is most commonly used in elderly AML is the “3 + 7 regime” which is also applied in younger AML patients and consists of 3 days of daunorubicin (45?
Regulation (regime) of Gene_expression (used) of AML associated with myeloid leukemia
13) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902223 Disease Relevance 0.59 Pain Relevance 0.09

General Comments

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