INT245537

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.00
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
sensory neurons 1
nociceptor 1
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 131 99.40 Very High Very High Very High
trigeminal ganglion 303 99.32 Very High Very High Very High
Neuropeptide 22 97.44 Very High Very High Very High
dorsal root ganglion 165 88.24 High High
mu opioid receptor 16 67.60 Quite High
calcitonin gene related peptide 44 63.52 Quite High
Dorsal horn 3 60.96 Quite High
Spinal cord 38 55.96 Quite High
Central nervous system 14 53.72 Quite High
Acute pain 4 19.48 Low Low
Disease Link Frequency Relevance Heat
Repression 37 100.00 Very High Very High Very High
Targeted Disruption 223 99.96 Very High Very High Very High
Ganglion Cysts 514 99.32 Very High Very High Very High
Cancer 9 98.36 Very High Very High Very High
Apoptosis 6 96.12 Very High Very High Very High
Osteoporosis 3 92.84 High High
Bone Cancer 3 86.80 High High
Nociception 48 85.32 High High
Leukemia 6 80.88 Quite High
Hematological Disease 6 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Runx3 may lead to the failure of TrkB and TrkC to segregate into distinct lineages, consistent with previous work demonstrating that Runx3 represses TrkB expression while promoting expression of TrkC [23,44].
Negative_regulation (Loss) of Runx3
1) Confidence 0.56 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.27 Pain Relevance 0.16
Nearly complete loss of Runx3 in the Brn3a-/- TG from the time of normal onset of its expression is suggestive of direct regulation.
Negative_regulation (loss) of Runx3 associated with trigeminal ganglion
2) Confidence 0.56 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.36
At birth, the TG of Brn3a-/- mice exhibit a profound loss of TrkC, Runx3, and multiple nociceptor channels and receptors, while sensory neuropeptide expression is maintained.
Negative_regulation (loss) of Runx3 in nociceptor associated with nociceptor, trigeminal ganglion and neuropeptide
3) Confidence 0.56 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.59 Pain Relevance 0.44
Hypermethylation of the RUNX3 promoter and deletion of the RUNX3 gene are frequently observed in several cancers, and RUNX3 protein is now best considered as an apoptosis inducer [11,12].
Negative_regulation (deletion) of RUNX3 associated with cancer and apoptosis
4) Confidence 0.42 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.11 Pain Relevance 0.10
Other neurological phenotypes of Runx1/Runx3 knockout mice
Negative_regulation (phenotypes) of Runx3 associated with targeted disruption
5) Confidence 0.42 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.11
Runx3 repression of TrkB expression appears to be mediated by direct binding of Runx3 to the Ntrk2 locus [44].
Negative_regulation (repression) of Runx3 associated with repression
6) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.20
Microarray studies have shown decreased levels of Runx1 and Runx3 transcripts in the sensory neurons of Brn-3a-knokout mice [40,41].
Negative_regulation (decreased) of Runx3 in sensory neurons
7) Confidence 0.19 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.17

General Comments

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