INT245538

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 11.68
Pain Relevance 9.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
neurons 16
ganglion 6
neuronal 4
embryos 4
nociceptors 4
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 753 100.00 Very High Very High Very High
nociceptor 612 100.00 Very High Very High Very High
dorsal root ganglion 237 99.84 Very High Very High Very High
Cholecystokinin 84 99.32 Very High Very High Very High
parabrachial 32 98.56 Very High Very High Very High
sodium channel 3 90.84 High High
nav1.8 16 90.24 High High
Pain 91 89.08 High High
monoamine 4 88.40 High High
medulla 54 87.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1096 100.00 Very High Very High Very High
Targeted Disruption 543 99.84 Very High Very High Very High
Nociception 105 98.60 Very High Very High Very High
Embryonic Lethality 3 90.72 High High
Pain 110 89.08 High High
Death 29 87.68 High High
Inflammatory Pain 57 87.36 High High
Neuropathic Pain 136 84.68 Quite High
Hematological Disease 6 81.68 Quite High
Repression 83 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Runx1 expression in neurons of the superior lateral parabrachial nucleus in Atoh1-deficient mice
Negative_regulation (Loss) of Gene_expression (expression) of Runx1 in lateral associated with parabrachial
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.33
In the Brn3a knockout TG we observed a marked reduction in the level of Runx1 expression (Figure 2I, J), and the number of cells positive for Runx1 was reduced by an average of 64% across the extent of the ganglion (Figure 2K).
Negative_regulation (reduction) of Gene_expression (expression) of Runx1 in ganglion associated with ganglion cysts, targeted disruption and trigeminal ganglion
2) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.73 Pain Relevance 0.33
Correction for cell loss using Islet1 to identify surviving neurons within the ganglion showed that the proportion of cells in the ganglion positive for Runx1 was reduced from 34 ± 3% to 18 ± 3% (Figure 2L), demonstrating a specific reduction in Runx1 expression in the absence of Brn3a.
Negative_regulation (reduction) of Gene_expression (expression) of Runx1 in ganglion associated with ganglion cysts
3) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.79 Pain Relevance 0.42
This suggests that Runx1 promotes TrkC expression in late-developing cutaneous neurons in Runx3 knockouts, but not in Brn3a-/- ganglia in which both Runx1 and Runx3 expression are severely attenuated.


Negative_regulation (attenuated) of Gene_expression (expression) of Runx1 in neurons
4) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.37 Pain Relevance 0.74
Runx1 expression is severely attenuated in the TG of Brn3a-/- embryos at E12.5 (Figure 5C, D), and recovers only to a small extent later in development (Figures 5G, H and 2I, J).
Negative_regulation (attenuated) of Gene_expression (expression) of Runx1 in embryos associated with trigeminal ganglion
5) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.20
In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors.
Negative_regulation (attenuated) of Gene_expression (expression) of Runx1 in neurons associated with nociceptor
6) Confidence 0.55 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.57 Pain Relevance 0.36
Peptidergic neurons maintain expression of TrkA, lose Runx1 expression, and never express Ret [2,7,38].
Negative_regulation (lose) of Gene_expression (expression) of Runx1 in Peptidergic neurons
7) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.66 Pain Relevance 0.32
Runx1 expression in these cells is first observed at approximately gestational day 12.5, persists into the adult brain, and is lost in knockout mice lacking the transcription factor Atoh1, an important regulator of the development of neuronal lineages of the rhombic lip.
Negative_regulation (lost) of Gene_expression (expression) of Runx1 in neuronal associated with targeted disruption
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0.10 Pain Relevance 0.20
Runx1 expression in these cells is first observed at approximately gestational day 12.5, persists into the adult brain, and is lost in knockout mice lacking the transcription factor Atoh1, an important regulator of the development of neuronal lineages of the rhombic lip.
Negative_regulation (persists) of Gene_expression (expression) of Runx1 in neuronal associated with targeted disruption
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0.10 Pain Relevance 0.19
The absence of Runx1 expression in the LPBS of Atoh1–/– mice provides evidence that the Runx1-expressing neurons of this region are derived from Atoh1-expressing progenitors.


Negative_regulation (absence) of Gene_expression (expression) of Runx1 in neurons
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.35
In lumbar DRG of L-CKO mice, Runx1 expression was not affected at E14.5, detected robustly at E16, but virtually absent at E17 (See Additional file 1).
Negative_regulation (absent) of Gene_expression (expression) of Runx1
11) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.69 Pain Relevance 0.84
In these late knockout mice, the expression of a subset of Runx1-dependent genes was affected, namely those in Runx1-persistent nociceptors, whereas expression of a separate set of Runx1-dependent genes that are normally expressed in Runx1-transient nociceptors was largely unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of Runx1 in nociceptors associated with targeted disruption and nociceptor
12) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.09 Pain Relevance 1.47
However, Runx1 expression is not maintained to the neonate stage and the expression of all putative Runx1 target genes is altered [42].
Neg (not) Negative_regulation (maintained) of Gene_expression (expression) of Runx1
13) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.67 Pain Relevance 0.24
What is clear, however, is that elimination of Runx1 expression is absolutely essential for the development of TrkA+;CGRP+ nociceptors (Fig. 4) [17].
Negative_regulation (elimination) of Gene_expression (expression) of Runx1 in nociceptors associated with nociceptor
14) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.16 Pain Relevance 0.86
Roles of Runx1 in the development of DRG neurons
Negative_regulation (development) of Gene_expression (Roles) of Runx1 in neurons associated with dorsal root ganglion
15) Confidence 0.42 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.14 Pain Relevance 0.54
In Ngf-Bax compound knockout DRG, TrkA neurons are hypotrophic although de novo Runx1 expression is unaffected [42].
Negative_regulation (de novo) of Gene_expression (expression) of Runx1 in neurons associated with targeted disruption and dorsal root ganglion
16) Confidence 0.42 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.21
Runx1 expression is severely attenuated in the TG of Brn3a-/- embryos at E12.5 (Figure 5C, D), and recovers only to a small extent later in development (Figures 5G, H and 2I, J).
Negative_regulation (recovers) of Gene_expression (expression) of Runx1 in embryos associated with trigeminal ganglion
17) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.50 Pain Relevance 0.20
The Brn3a-/- TG exhibits a profound decrease in the expression of both Runx3 and Runx1, and failure to appropriately activate Runx expression can account for much of the early developmental phenotype of the Brn3a-/- TG.
Negative_regulation (decrease) of Gene_expression (expression) of Runx1 associated with trigeminal ganglion
18) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.49 Pain Relevance 0.43
However, ectopic expression of Runx1 in E12.5 DRG represses TrkB expression, promotes both TrkA and TrkC, and appears to be interchangeable with Runx3 in these effects [23].
Negative_regulation (represses) of Gene_expression (expression) of Runx1
19) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.33 Pain Relevance 0.39
Correction for cell loss using Islet1 to identify surviving neurons within the ganglion showed that the proportion of cells in the ganglion positive for Runx1 was reduced from 34 ± 3% to 18 ± 3% (Figure 2L), demonstrating a specific reduction in Runx1 expression in the absence of Brn3a.
Negative_regulation (reduction) of Gene_expression (expression) of Runx1 in ganglion associated with ganglion cysts
20) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.79 Pain Relevance 0.42

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