INT245539

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.11
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 1
ganglia 1
telomere 1
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 227 99.96 Very High Very High Very High
nociceptor 98 89.20 High High
dorsal root ganglion 110 70.96 Quite High
Potency 4 60.80 Quite High
Acute pain 3 49.52 Quite Low
Serotonin 6 38.68 Quite Low
calcitonin gene related peptide 33 5.00 Very Low Very Low Very Low
Spinal cord 26 5.00 Very Low Very Low Very Low
Neuropeptide 16 5.00 Very Low Very Low Very Low
mu opioid receptor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 371 99.96 Very High Very High Very High
Cancer 6 99.20 Very High Very High Very High
Apoptosis 11 96.12 Very High Very High Very High
Bone Cancer 2 88.52 High High
Leukemia 4 82.60 Quite High
Hematological Disease 4 80.88 Quite High
Aging 1 78.32 Quite High
Targeted Disruption 165 74.72 Quite High
Embryonal Carcinoma 2 68.44 Quite High
Repression 27 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypermethylation of the RUNX3 promoter and deletion of the RUNX3 gene are frequently observed in several cancers, and RUNX3 protein is now best considered as an apoptosis inducer [11,12].
Positive_regulation (Hypermethylation) of RUNX3 associated with cancer and apoptosis
1) Confidence 0.49 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.01 Pain Relevance 0.07
Hypermethylation of the RUNX3 promoter and deletion of the RUNX3 gene are frequently observed in several cancers, and RUNX3 protein is now best considered as an apoptosis inducer [11,12].
Positive_regulation (Hypermethylation) of RUNX3 associated with cancer and apoptosis
2) Confidence 0.49 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.13 Pain Relevance 0.10
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Positive_regulation (populations) of Runx3 in ganglia
3) Confidence 0.48 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
Although Brn3a binds directly to a Runx3 enhancer element, it is clear that this is a necessary but not sufficient condition for the initiation of Runx3 expression since Brn3a is widely expressed at the onset of Runx3 expression, yet Runx3 is only initiated in a subset of Brn3a neurons.
Positive_regulation (initiated) of Runx3 in neurons
4) Confidence 0.44 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.06 Pain Relevance 0
In control TG, Runx3 expression follows TrkC by one developmental day.
Spec (appears) Positive_regulation (follows) of Runx3 associated with trigeminal ganglion
5) Confidence 0.21 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.63 Pain Relevance 0.48
The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).
Positive_regulation (upregulation) of RUNX3 in telomere
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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