INT245544

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.52
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
Neuronal 3
neurons 1
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 76 98.44 Very High Very High Very High
depression 365 96.96 Very High Very High Very High
Neuropeptide 6 90.12 High High
dorsal root ganglion 55 89.52 High High
nociceptor 33 88.08 High High
antidepressant 310 59.28 Quite High
Eae 20 55.48 Quite High
Central nervous system 29 40.04 Quite Low
Spinal cord 12 24.20 Low Low
Nerve growth factor 21 15.28 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 143 98.44 Very High Very High Very High
Suicidal Behaviour 615 97.28 Very High Very High Very High
Depression 475 96.96 Very High Very High Very High
Apoptosis 32 93.20 High High
Disease Susceptibility 5 91.76 High High
Stress 125 91.36 High High
Mental Disorders 30 90.92 High High
Targeted Disruption 90 86.68 High High
Death 24 80.96 Quite High
Nociception 15 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, what role does dendritic localization of BDNF/TrkB play in altered plasticity in these disorders?
Localization (localization) of TrkB
1) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.74 Pain Relevance 0.14
TrkB is primarily localized in the synaptic sites.
Localization (localized) of TrkB
2) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.18 Pain Relevance 0.06
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Localization (localization) of TrkB in Neuronal
3) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.24 Pain Relevance 0.09
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Localization (targeting) of TrkB in Neuronal
4) Confidence 0.72 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.40 Pain Relevance 0.17
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Localization (release) of TrkB in Neuronal
5) Confidence 0.72 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.42 Pain Relevance 0.18
At midgestation, Brn3a-/- TG show expanded TrkB expression compared to wild type, resulting in failure to segregate TrkB+ from TrkC+ and TrkA+ neurons, effects that are consistent with the loss of Runx function.
Neg (failure) Localization (segregate) of TrkB in neurons associated with trigeminal ganglion
6) Confidence 0.71 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 0.37
They observed that Runx3 co-localizes not only with TrkC, but also TrkA and TrkB at postnatal day 0 (P0) [30].
Localization (localizes) of TrkB
7) Confidence 0.29 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.01 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox