INT245553

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) nucleus (Runx1)
DNA binding (Runx1) kinase activity (Ntrk1) transcription factor binding (Runx1)
Anatomy Link Frequency
embryos 2
Runx1 (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 79 99.84 Very High Very High Very High
Spinal cord 16 99.36 Very High Very High Very High
Neuropeptide 2 67.92 Quite High
Nerve growth factor 5 59.56 Quite High
Peripheral nervous system 3 58.32 Quite High
nociceptor 9 50.64 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
trigeminal ganglion 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 82 99.84 Very High Very High Very High
Death 3 98.56 Very High Very High Very High
Targeted Disruption 21 91.56 High High
Nociception 21 90.72 High High
Repression 3 79.28 Quite High
Neurodegenerative Disease 6 55.56 Quite High
Hematological Disease 2 51.84 Quite High
Embryonic Lethality 1 47.56 Quite Low
Cancer 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Marmigere et al. [35] showed that virally expressed Runx1 induced de novo synthesis of TrkA in the DRG and spinal cord of chick embryos.
Runx1 Positive_regulation (induced) of Gene_expression (synthesis) of TrkA in embryos associated with dorsal root ganglion and spinal cord
1) Confidence 0.45 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.75 Pain Relevance 0.26
This suggests that Runx1 might have an effect on early progenitors by inducing TrkA expression in DRG precursors.
Runx1 Positive_regulation (inducing) of Gene_expression (expression) of TrkA associated with dorsal root ganglion
2) Confidence 0.38 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.66 Pain Relevance 0.27

General Comments

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