INT245564

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.61
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
nucleus (Runx3) DNA binding (Runx3) kinase activity (Ntrk2)
Anatomy Link Frequency
nociceptors 1
Runx3 (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 34 97.68 Very High Very High Very High
dorsal root ganglion 110 95.36 Very High Very High Very High
trigeminal ganglion 77 90.64 High High
Spinal cord 22 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 77 97.76 Very High Very High Very High
Ganglion Cysts 201 95.36 Very High Very High Very High
Repression 13 80.24 Quite High
Nociception 27 35.52 Quite Low
Osteoporosis 2 20.40 Low Low
Neurodegenerative Disease 11 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is likely that both Runx1 and Runx3 function to repress TrkB and promote the exclusive expression of TrkA and TrkC in nociceptors and proprioceptors, respectively.
Runx3 Negative_regulation (repress) of TrkB in nociceptors associated with nociceptor
1) Confidence 0.61 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.38 Pain Relevance 0.42
The results suggest that Runx3 represses trkB through a Groucho independent mechanism.
Runx3 Negative_regulation (represses) of trkB
2) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.70 Pain Relevance 0.18
The finding that Runx3 represses trkB raises a question as to the identities of its partner molecules in the transcriptional repressor complex.
Runx3 Negative_regulation (represses) of trkB
3) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.54 Pain Relevance 0.19

General Comments

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