INT245577

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 10.43
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
Anatomy Link Frequency
lung 4
pericardium 2
synovial fluid 1
pneumocytes 1
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 110 99.84 Very High Very High Very High
positron emission tomography 40 97.76 Very High Very High Very High
chemokine 2 96.56 Very High Very High Very High
imagery 30 95.76 Very High Very High Very High
Inflammation 199 94.56 High High
cytokine 22 88.32 High High
Inflammatory mediators 36 86.04 High High
Angina 13 80.16 Quite High
Pain 3 39.68 Quite Low
Thoracotomy 2 30.16 Quite Low
Disease Link Frequency Relevance Heat
Pleural Solitary Fibrous Tumor 128 100.00 Very High Very High Very High
Cancer 95 100.00 Very High Very High Very High
Salivary Gland Disease 4 100.00 Very High Very High Very High
Rheumatoid Arthritis 110 99.84 Very High Very High Very High
Lung Injury 3 99.00 Very High Very High Very High
Hypoglycemia 6 97.80 Very High Very High Very High
INFLAMMATION 238 94.56 High High
Syndrome 17 94.36 High High
Charcot Marie Tooth Disease 1 93.68 High High
Pulmonary Disease 196 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Baseline SP-D did not predict radiographic progression (Total Sharp score) at four years (P = 0.46)

SP-D in synovial fluid and corresponding sera

Localization (Baseline) of SP-D in synovial fluid
1) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.57 Pain Relevance 0.09
Decreased SP-D in RA could be attributable to increased clearance from the circulation, for example, by deposition in inflamed tissues or complex formation with, for example, microbial or cellular waste [36,37].
Localization (Decreased) of SP-D associated with rheumatoid arthritis
2) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.96 Pain Relevance 0.29
Solitary fibrous tumor of the pleura (SFTP), first described as a distinct clinical entity by Klemperer and Rabin in 1931,1 is a mesenchymal neoplasm which usually involves the pleura, but it can occur in other thoracic areas (mediastinum, pericardium, and lung) as well as in extra-thoracic areas (meninx, epiglottis, salivary glands, thyroid, kidneys and breast).2,3 SFTP occurs with equal frequency in both sexes and is more commonly found in the fourth, fifth, and sixth decades of life.4
Localization (found) of SFTP in pericardium associated with salivary gland disease, cancer and pleural solitary fibrous tumor
3) Confidence 0.52 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.98 Pain Relevance 0.18
Solitary fibrous tumor of the pleura (SFTP), first described as a distinct clinical entity by Klemperer and Rabin in 1931,1 is a mesenchymal neoplasm which usually involves the pleura, but it can occur in other thoracic areas (mediastinum, pericardium, and lung) as well as in extra-thoracic areas (meninx, epiglottis, salivary glands, thyroid, kidneys and breast).2,3 SFTP occurs with equal frequency in both sexes and is more commonly found in the fourth, fifth, and sixth decades of life.4
Localization (found) of SFTP in pericardium associated with salivary gland disease, cancer and pleural solitary fibrous tumor
4) Confidence 0.52 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.96 Pain Relevance 0.16
Serum SP-A and SP-D are hydrophilic surfactant proteins produced and secreted by type II pneumocytes.
Localization (secreted) of SP-D in pneumocytes
5) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.57 Pain Relevance 0.10
In less than 5% of cases, SFTP can secrete insulin-like growth factor II which causes refractory hypoglycemia [1,7].
Localization (secrete) of SFTP associated with hypoglycemia and pleural solitary fibrous tumor
6) Confidence 0.32 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2531110 Disease Relevance 2.34 Pain Relevance 0
Second, experimental studies in mice suggest that lung injury induced by bleomycin exposure leads to increased leak of surfactant protein D (SP-D), a lung specific protein from the pulmonary to the systemic compartment [39].
Localization (leak) of SP-D in lung associated with lung injury
7) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.05 Pain Relevance 0.34
Second, experimental studies in mice suggest that lung injury induced by bleomycin exposure leads to increased leak of surfactant protein D (SP-D), a lung specific protein from the pulmonary to the systemic compartment [39].
Localization (leak) of surfactant protein D in lung associated with lung injury
8) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.05 Pain Relevance 0.34
Solitary fibrous tumor of the pleura (SFTP), first described as a distinct clinical entity by Klemperer and Rabin in 1931,1 is a mesenchymal neoplasm which usually involves the pleura, but it can occur in other thoracic areas (mediastinum, pericardium, and lung) as well as in extra-thoracic areas (meninx, epiglottis, salivary glands, thyroid, kidneys and breast).2,3 SFTP occurs with equal frequency in both sexes and is more commonly found in the fourth, fifth, and sixth decades of life.4
Localization (found) of SFTP in lung associated with salivary gland disease, cancer and pleural solitary fibrous tumor
9) Confidence 0.18 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.98 Pain Relevance 0.18
Solitary fibrous tumor of the pleura (SFTP), first described as a distinct clinical entity by Klemperer and Rabin in 1931,1 is a mesenchymal neoplasm which usually involves the pleura, but it can occur in other thoracic areas (mediastinum, pericardium, and lung) as well as in extra-thoracic areas (meninx, epiglottis, salivary glands, thyroid, kidneys and breast).2,3 SFTP occurs with equal frequency in both sexes and is more commonly found in the fourth, fifth, and sixth decades of life.4
Localization (found) of SFTP in lung associated with salivary gland disease, cancer and pleural solitary fibrous tumor
10) Confidence 0.18 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.96 Pain Relevance 0.16

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