INT245584

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.46
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
plasma 6
liver 2
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 48 87.20 High High
Thalamus 32 85.44 High High
amygdala 4 76.08 Quite High
anesthesia 2 49.92 Quite Low
antagonist 2 8.04 Low Low
cerebral cortex 22 5.00 Very Low Very Low Very Low
Eae 16 5.00 Very Low Very Low Very Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 12 100.00 Very High Very High Very High
Obesity 28 99.90 Very High Very High Very High
Targeted Disruption 178 99.72 Very High Very High Very High
Hyperglycemia 4 93.20 High High
Cognitive Disorder 40 83.44 Quite High
Body Weight 40 78.72 Quite High
Peripheral Arterial Disease 4 71.68 Quite High
Insulin Resistance 4 59.52 Quite High
Nociception 8 39.48 Quite Low
Anxiety Disorder 32 33.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the GIR was significantly higher in KO mice compared to WT (7.76 ± 1.65 vs 5.68 ± 1.52 mg/kg/min, Figure 2C), indicative of increased insulin sensitivity of the GhrR KO mice.
Positive_regulation (increased) of Gene_expression (sensitivity) of GhrR associated with hyperinsulinism
1) Confidence 0.41 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.87 Pain Relevance 0
Preliminary experiments were performed comparing diet-induced obese (DIO) vs lean mice prior to conducting experiments on HFD-fed GhrR KO vs WT mice (Figure 1).


Positive_regulation (experiments) of Gene_expression (lean) of GhrR associated with obesity
2) Confidence 0.41 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.43 Pain Relevance 0
Indeed our group has already shown that PTPH1-KO mice display higher GHR response in vivo and consequently a higher expression of its down-stream effector hormone, the IGF1 in liver and plasma [22].
Positive_regulation (higher) of Gene_expression (expression) of GHR in plasma associated with targeted disruption
3) Confidence 0.29 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.19
Indeed our group has already shown that PTPH1-KO mice display higher GHR response in vivo and consequently a higher expression of its down-stream effector hormone, the IGF1 in liver and plasma [22].
Positive_regulation (higher) of Gene_expression (expression) of GHR in plasma associated with targeted disruption
4) Confidence 0.29 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.19
Indeed our group has already shown that PTPH1-KO mice display higher GHR response in vivo and consequently a higher expression of its down-stream effector hormone, the IGF1 in liver and plasma [22].
Positive_regulation (higher) of in liver Gene_expression (expression) of GHR in plasma associated with targeted disruption
5) Confidence 0.10 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.19
Indeed our group has already shown that PTPH1-KO mice display higher GHR response in vivo and consequently a higher expression of its down-stream effector hormone, the IGF1 in liver and plasma [22].
Positive_regulation (higher) of in liver Gene_expression (expression) of GHR in plasma associated with targeted disruption
6) Confidence 0.10 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.19

General Comments

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