INT245586

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
body 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 2 95.64 Very High Very High Very High
nMDA receptor 1 59.24 Quite High
Sciatic nerve 1 53.40 Quite High
Eae 4 46.08 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 2 97.28 Very High Very High Very High
Targeted Disruption 44 95.84 Very High Very High Very High
Anxiety Disorder 8 43.44 Quite Low
Cognitive Disorder 10 35.88 Quite Low
Nociception 2 30.64 Quite Low
Apoptosis 1 13.40 Low Low
Overdose 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, our group has demonstrated that PTPH1 dephosphorylates GHR in vitro and in cellular assays [21] and results in an increase of body weight in the functional PTPH1-knockout (KO) mice via modulation of IGF1 secretion [22] thus demonstrating its in vivo relevance.
Phosphorylation (dephosphorylates) of GHR in body associated with targeted disruption and body weight
1) Confidence 0.44 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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