INT245590

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghr, Igf1) extracellular region (Ghr, Igf1) mitochondrion (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
body 2
Ghr (Mus musculus)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 4 96.08 Very High Very High Very High
Pain 1 90.16 High High
Pyramidal cell 3 72.20 Quite High
Hippocampus 12 54.44 Quite High
midbrain 2 41.40 Quite Low
Thalamus 8 40.84 Quite Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 44 98.10 Very High Very High Very High
Body Weight 2 97.50 Very High Very High Very High
Anxiety Disorder 8 93.12 High High
Pain 1 90.16 High High
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased body weight has been detected in PTPH1-KO mice compared to WT littermates, more pronounced in male mice and probably due to an enhanced GHR sensitivity, that leads to increased IGF-1 mRNA and protein expression in liver and plasma, respectively [22].
GHR Positive_regulation (increased) of Gene_expression (expression) of IGF-1 mRNA in body associated with targeted disruption and body weight
1) Confidence 0.34 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.61 Pain Relevance 0.23

General Comments

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