INT245593

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 32
Total Number 41
Disease Relevance 10.68
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PTPN3) plasma membrane (PTPN3) cytoskeleton (PTPN3)
cytoplasm (PTPN3)
Anatomy Link Frequency
brain 5
cerebellum 2
hippocampus 2
cortex 2
neurons 2
PTPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 210 99.48 Very High Very High Very High
Inflammatory response 35 99.26 Very High Very High Very High
Hippocampus 396 98.92 Very High Very High Very High
Pyramidal cell 99 98.92 Very High Very High Very High
Spinal cord 66 97.56 Very High Very High Very High
cerebral cortex 165 97.08 Very High Very High Very High
Thalamus 264 97.04 Very High Very High Very High
nMDA receptor 33 95.04 Very High Very High Very High
Eae 132 94.48 High High
Limbic system 33 92.00 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 1459 100.00 Very High Very High Very High
Body Weight 66 99.62 Very High Very High Very High
INFLAMMATION 245 99.48 Very High Very High Very High
Urological Neuroanatomy 33 99.44 Very High Very High Very High
Cognitive Disorder 330 98.44 Very High Very High Very High
Anxiety Disorder 264 93.16 High High
Nociception 94 89.68 High High
Volume Depletion And Dehydration 33 89.00 High High
Overdose 87 87.44 High High
Rheumatoid Arthritis 7 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTPH1 has been shown in the rat to be highly expressed in thalamic nuclei as well as various cortical areas [10].
Gene_expression (expressed) of PTPH1
1) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.49 Pain Relevance 0.10
Indeed PTPH1 expression is also detectable in the pyramidal neurons in layer III and IVA of the cerebral cortex of the mouse (Figures 2a, 2b), in agreement with Sahin's findings in the rat brain.
Gene_expression (expression) of PTPH1 in pyramidal neurons associated with pyramidal cell and cerebral cortex
2) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.22 Pain Relevance 0.28
We, furthermore, demonstrate that PTPH1 is expressed within the cytoplasm and close to the cell membrane of neurons in most of the brain area investigated (Figures 4a, 4b).
Gene_expression (expressed) of PTPH1 in neurons
3) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.14 Pain Relevance 0.19
LacZ staining was performed on frozen brain sections to confirm and to describe the expression of PTPH1 at the brain structural level (Table 2).
Gene_expression (expression) of PTPH1 in brain
4) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.17 Pain Relevance 0.22
It is known that the FERM domain is indeed necessary for PTPH1 localization close to the plasma membrane in Jurkat T cells [14] and it could be responsible for the punctate expression pattern of PTPH1 in the cytosol of the neurons (Figure 4b) [39].
Gene_expression (expression) of PTPH1 in neurons
5) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.18
On the other hand, the CNS expression at P1 appears weaker than in the adults suggesting a pattern of PTPH1 expression corresponding to specific developmental stages of the CNS as well as peripheral organs (data not shown).
Gene_expression (expression) of PTPH1 in developmental stages
6) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.23 Pain Relevance 0.19
Indeed the neural expression of PTPH1 in CA1, CA3 and DG of the hippocampus (Figures 9a, 9b, 9c, 9d and 9e), in the retrosplenial cortex (Figures 3, 4) and in a series of thalamic nuclei (Figures 7a, 7b, 7c, 7d and 7e) suggests an involvement of PTPH1 in the modulation of the memory circuit.
Spec (suggests) Gene_expression (expression) of PTPH1 in hippocampus associated with hippocampus
7) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.11 Pain Relevance 0.18
The cerebellar cortex is also positive for PTPH1 expression, in particular in the cytoplasm of granule cells (Figure 5b).
Gene_expression (expression) of PTPH1 in granule cells
8) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.15
In PTPH1-KO adults, LacZ is expressed in different CNS areas such as cerebral and retrosplenial cortices (Figures 1, 2, 3 and 4), hippocampus (Figure 9), thalamus (preferentially ventral thalamus) (Figure 7), cerebellum (Figure 5) and in the region of the tenia tecta (Figures 1, 8).
Gene_expression (expressed) of PTPH1 in cerebellum associated with targeted disruption, thalamus and hippocampus
9) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.23 Pain Relevance 0.22
PTPH1 expression in the granule cells seems to indicate a potential involvement in the processing of afferent information to the purkinje cells, since it is known that afferents fibers to the cerebellar cortex will project in part through the granule cell layer.
Gene_expression (expression) of PTPH1 in cerebellar cortex
10) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.11 Pain Relevance 0.10
Moreover, at postnatal P1, PTPH1 expression is also present in peripheral organs such as muscles and intestines as in the adults [22].
Gene_expression (expression) of PTPH1 in intestines
11) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.23 Pain Relevance 0.26
PTPH1 expression pattern observed in our analysis points out a potential involvement of this phosphatase in numerous CNS processing functions such as locomotion, sensorial integration, learning and memory.
Gene_expression (expression) of PTPH1
12) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.21 Pain Relevance 0.08
PTPH1 is expressed in the hypothalamic area and but also in the dorsal root ganglia of the spinal cord, excluding the spinal cord itself [Additional file 1] [38].
Gene_expression (expressed) of PTPH1 in spinal cord associated with spinal cord
13) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.18 Pain Relevance 0.19
The organs and the tissues in the sections display a green/blue staining where PTPH1 gene is normally expressed.
Gene_expression (expressed) of PTPH1
14) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.44 Pain Relevance 0
The expression of PTPH1 in these specific regions suggests a potential role in the processing/integration of memory and sensory information to the SHi and likely the cortex.
Gene_expression (expression) of PTPH1 in cortex
15) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.24 Pain Relevance 0.27
Indeed PTPH1 has been shown to be expressed in the CNS [10] but little is currently known on its potential impact on CNS functions.
Gene_expression (expressed) of PTPH1
16) Confidence 0.38 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.09
Semiquantitative RT-PCR for PTPH1 and beta-gal gene expression was performed in different brain areas of PTPH1-KO and WT mice in order to confirm the presence of beta-gal expression in the KO tissues, replacing PTPH1 PDZ and catalytic domain.
Gene_expression (expression) of PTPH1 in brain associated with targeted disruption
17) Confidence 0.33 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.42 Pain Relevance 0.08
As reported in Pilecka et al., our PTPH1-KO mice express the non-catalytic part of PTPH1 in frame with the enzymatically active part of LacZ gene.
Gene_expression (express) of PTPH1 associated with targeted disruption
18) Confidence 0.33 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.62 Pain Relevance 0
PTPH1 KO design
Gene_expression (design) of PTPH1 associated with targeted disruption
19) Confidence 0.33 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.59 Pain Relevance 0.03
Recently, our group has demonstrated that PTPH1 dephosphorylates GHR in vitro and in cellular assays [21] and results in an increase of body weight in the functional PTPH1-knockout (KO) mice via modulation of IGF1 secretion [22] thus demonstrating its in vivo relevance.
Gene_expression (modulation) of PTPH1 in body associated with targeted disruption and body weight
20) Confidence 0.33 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.43 Pain Relevance 0.10

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