INT245596

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.92
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PTPN3) plasma membrane (PTPN3) cytoskeleton (PTPN3)
cytoplasm (PTPN3)
Anatomy Link Frequency
neurons 4
T cells 2
body 2
granule cells 2
PTPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 8 92.60 High High
cerebral cortex 20 83.88 Quite High
Thalamus 32 81.84 Quite High
Hippocampus 48 79.68 Quite High
rheumatoid arthritis 1 77.76 Quite High
Pyramidal cell 12 76.60 Quite High
Limbic system 4 59.12 Quite High
Eae 16 57.04 Quite High
nMDA receptor 4 56.20 Quite High
Spinal cord 8 53.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 177 100.00 Very High Very High Very High
Body Weight 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 1 77.76 Quite High
Diabetes Mellitus 1 76.56 Quite High
Autoimmune Disease 1 75.80 Quite High
Urological Neuroanatomy 4 66.56 Quite High
Anxiety Disorder 32 54.40 Quite High
INFLAMMATION 35 50.72 Quite High
Nociception 12 41.60 Quite Low
Brain Injury 4 40.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, our group has demonstrated that PTPH1 dephosphorylates GHR in vitro and in cellular assays [21] and results in an increase of body weight in the functional PTPH1-knockout (KO) mice via modulation of IGF1 secretion [22] thus demonstrating its in vivo relevance.
Positive_regulation (increase) of Gene_expression (modulation) of PTPH1 in body associated with targeted disruption and body weight
1) Confidence 0.25 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.43 Pain Relevance 0.13
The cerebellar cortex is also positive for PTPH1 expression, in particular in the cytoplasm of granule cells (Figure 5b).
Positive_regulation (positive) of Gene_expression (expression) of PTPH1 in granule cells
2) Confidence 0.23 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.15
It is known that the FERM domain is indeed necessary for PTPH1 localization close to the plasma membrane in Jurkat T cells [14] and it could be responsible for the punctate expression pattern of PTPH1 in the cytosol of the neurons (Figure 4b) [39].
Positive_regulation (responsible) of Gene_expression (expression) of PTPH1 in neurons
3) Confidence 0.23 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.18
It is known that the FERM domain is indeed necessary for PTPH1 localization close to the plasma membrane in Jurkat T cells [14] and it could be responsible for the punctate expression pattern of PTPH1 in the cytosol of the neurons (Figure 4b) [39].
Positive_regulation (necessary) of Gene_expression (expression) of PTPH1 in neurons
4) Confidence 0.23 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.24
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTPH1 in T cells
5) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.28 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox