INT245599

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.57
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PTPN3) plasma membrane (PTPN3) cytoskeleton (PTPN3)
cytoplasm (PTPN3)
Anatomy Link Frequency
neurons 2
brain 2
granule cells 2
PTPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 36 86.00 High High
cerebral cortex 15 83.88 Quite High
midbrain 6 82.56 Quite High
Thalamus 24 77.80 Quite High
Pyramidal cell 9 76.60 Quite High
Limbic system 3 59.12 Quite High
Spinal cord 6 49.68 Quite Low
Eae 12 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 132 100.00 Very High Very High Very High
Volume Depletion And Dehydration 3 89.00 High High
Urological Neuroanatomy 3 66.56 Quite High
Overdose 6 52.68 Quite High
Brain Injury 3 40.76 Quite Low
Cognitive Disorder 30 37.92 Quite Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semiquantitative RT-PCR for PTPH1 and beta-gal gene expression was performed in different brain areas of PTPH1-KO and WT mice in order to confirm the presence of beta-gal expression in the KO tissues, replacing PTPH1 PDZ and catalytic domain.
Regulation (presence) of Gene_expression (expression) of PTPH1 in brain associated with targeted disruption
1) Confidence 0.22 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.43 Pain Relevance 0.08
The cerebellar cortex is also positive for PTPH1 expression, in particular in the cytoplasm of granule cells (Figure 5b).
Regulation (positive) of Gene_expression (expression) of PTPH1 in granule cells
2) Confidence 0.22 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.15
It is known that the FERM domain is indeed necessary for PTPH1 localization close to the plasma membrane in Jurkat T cells [14] and it could be responsible for the punctate expression pattern of PTPH1 in the cytosol of the neurons (Figure 4b) [39].
Regulation (responsible) of Gene_expression (expression) of PTPH1 in neurons
3) Confidence 0.22 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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