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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Cdk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 33.04 Quite Low
dexamethasone 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 99.68 Very High Very High Very High
Cancer 6 94.16 High High
Apoptosis 1 90.64 High High
Skin Cancer 83 89.52 High High
Death 1 72.96 Quite High
Pancreatic Cancer 7 66.40 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Freckles 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, there is the down-regulation of cyclin D1, cyclin-dependent kinase 4, c-myc and Bcl-2 [19, 24].
Negative_regulation (regulation) of cyclin-dependent kinase 4
1) Confidence 0.18 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.09 Pain Relevance 0
One of those proteins is p16INK4A, which inhibits the CDK4/6 mediated phosphorilation and inactivation of Rb (retinoblastoma) protein.
Negative_regulation (inactivation) of CDK4 associated with retinoblastoma
2) Confidence 0.17 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2556318 Disease Relevance 1.15 Pain Relevance 0

General Comments

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