INT245633

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (FDX1) generation of precursor metabolites and energy (FDX1) mitochondrion (FDX1)
enzyme binding (FDX1)
Anatomy Link Frequency
dentate gyrus 1
FDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 96 96.00 Very High Very High Very High
fluoxetine 34 95.12 Very High Very High Very High
Central nervous system 3 78.44 Quite High
Catecholamine 6 67.48 Quite High
Morphine 1 63.28 Quite High
Dopamine 7 52.84 Quite High
Hippocampus 7 10.48 Low Low
withdrawal 7 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 58 96.40 Very High Very High Very High
Stress 16 93.52 High High
Recurrence 2 27.88 Quite Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, whereas surgical removal of the adrenals (adrenalectomy, “ADX”) prevented initiation and expression of psychomotor sensitization, replacement of corticosterone to concentrations similar or even higher than those induced by stress was not sufficient to fully reverse the effects of ADX (De Jong and De Kloet 2009).
Negative_regulation (removal) of ADX associated with stress
1) Confidence 0.10 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2687516 Disease Relevance 0.50 Pain Relevance 0.27
Microscopic analysis showed that growth of villi and crypts is age-dependent, and is significantly attenuated in ADX rats compared with sham-operated rats.
Negative_regulation (attenuated) of ADX
2) Confidence 0.06 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Proliferating progenitor cells in the dentate gyrus following ADX and corticosterone replacement in LH and SD rats
Negative_regulation (following) of ADX in dentate gyrus
3) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2650100 Disease Relevance 0.89 Pain Relevance 0.32

General Comments

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