INT245636

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
spinal 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 29 99.56 Very High Very High Very High
Hippocampus 30 96.72 Very High Very High Very High
dexamethasone 44 96.58 Very High Very High Very High
Pain 20 92.56 High High
corticosteroid 41 88.44 High High
Calcitonin gene-related peptide 32 85.92 High High
depression 2 83.00 Quite High
GABAergic 2 82.76 Quite High
medulla 3 79.60 Quite High
spinal dorsal horn 11 78.24 Quite High
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 27 98.32 Very High Very High Very High
Stress 66 94.12 High High
Pain 23 92.56 High High
Anxiety Disorder 10 85.12 High High
Depression 2 83.00 Quite High
Urological Neuroanatomy 3 81.48 Quite High
Traumatic Stress Disorders 2 61.16 Quite High
Syndrome 2 32.36 Quite Low
Nociception 25 25.68 Quite Low
Polycystic Ovary Syndrome 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The importance of the activation of MR and GR-mediated effect by glucocorticoid are observed in psychiatric disorders.
Regulation (importance) of Positive_regulation (activation) of MR
1) Confidence 0.59 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.30 Pain Relevance 0.19
Another alternative, but not exclusive, mechanism to explain the differential effect of DEX and CORT upon neuropeptidergic spinal expression derives from the specific modulatory effects of MR upon preprotachykinin (PPT), the precursor of SP expression; in fact, MR activation has been shown to positively regulate (up to 50%) mRNA PPT expression in the nervous tissues [48].
Regulation (regulate) of Positive_regulation (activation) of MR in spinal associated with dexamethasone and substance p
2) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.25 Pain Relevance 1.06

General Comments

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