INT245648

Context Info Confidence 0.49 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.53 Pain Relevance 0.59

protein modification process (SEPHS1)

Anatomy Link Frequency arm 1 SEPHS1 (Homo sapiens)

Pain Link Frequency Relevance Heat gABA 8 96.72 Hippocampus 58 92.88 corticosteroid 16 91.80 Central nervous system 2 87.72 Neurotransmitter 2 86.52 imagery 11 25.04 headache 10 5.00 Migraine 8 5.00 Pain 8 5.00 depression 4 5.00

Disease Link Frequency Relevance Heat Stress 114 100.00 Stiff-person Syndrome 68 100.00 Generalized Anxiety Disorder 24 100.00 Muscular Spasm 4 94.64 Esophageal Motility Disorder 2 93.24 Post-traumatic Stress Disorder 54 91.40 Congenital Anomalies 4 89.84 Syndrome 4 87.84 Disease 11 85.36 Lumbar Puncture Related Headaches 6 84.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The manifestation of stiffness in an arm, as opposed to the legs or the thoraco-lumbar spine, accompanied by weakness is a peculiar presentation of SPS.

Gene_expression (presentation) of SPS in arm associated with stiff-person syndrome

1) Confidence 0.49 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 0.90 Pain Relevance 0.12

The presence of GAD antibodies explains part of this pathophysiological process, because some patients with SPS are GAD antibody-negative.

Neg (negative) Gene_expression (negative) of SPS associated with generalized anxiety disorder and stiff-person syndrome

2) Confidence 0.44 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 1.61 Pain Relevance 0.23

The density of practicing SPs also varies between provinces from 8.4 SPs in rural areas to 24.0 SPs per 10 000 inhabitants in Brussels.

Gene_expression (practicing) of SPs

3) Confidence 0.27 Published 2010 Journal Hum Resour Health Section Body Doc Link PMC3017009 Disease Relevance 0.06 Pain Relevance 0

In the present study, we only studied the changes in expression of both receptors after SPS.

Gene_expression (expression) of SPS associated with stress

4) Confidence 0.01 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.55 Pain Relevance 0.12

In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS.

Gene_expression (expression) of SPS associated with stress

5) Confidence 0.01 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13

General Comments

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