INT245648

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.53
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (SEPHS1)
Anatomy Link Frequency
arm 1
SEPHS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 8 96.72 Very High Very High Very High
Hippocampus 58 92.88 High High
corticosteroid 16 91.80 High High
Central nervous system 2 87.72 High High
Neurotransmitter 2 86.52 High High
imagery 11 25.04 Quite Low
headache 10 5.00 Very Low Very Low Very Low
Migraine 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 114 100.00 Very High Very High Very High
Stiff-person Syndrome 68 100.00 Very High Very High Very High
Generalized Anxiety Disorder 24 100.00 Very High Very High Very High
Muscular Spasm 4 94.64 High High
Esophageal Motility Disorder 2 93.24 High High
Post-traumatic Stress Disorder 54 91.40 High High
Congenital Anomalies 4 89.84 High High
Syndrome 4 87.84 High High
Disease 11 85.36 High High
Lumbar Puncture Related Headaches 6 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The manifestation of stiffness in an arm, as opposed to the legs or the thoraco-lumbar spine, accompanied by weakness is a peculiar presentation of SPS.
Gene_expression (presentation) of SPS in arm associated with stiff-person syndrome
1) Confidence 0.49 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 0.90 Pain Relevance 0.12
The presence of GAD antibodies explains part of this pathophysiological process, because some patients with SPS are GAD antibody-negative.
Neg (negative) Gene_expression (negative) of SPS associated with generalized anxiety disorder and stiff-person syndrome
2) Confidence 0.44 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 1.61 Pain Relevance 0.23
The density of practicing SPs also varies between provinces from 8.4 SPs in rural areas to 24.0 SPs per 10 000 inhabitants in Brussels.
Gene_expression (practicing) of SPs
3) Confidence 0.27 Published 2010 Journal Hum Resour Health Section Body Doc Link PMC3017009 Disease Relevance 0.06 Pain Relevance 0
In the present study, we only studied the changes in expression of both receptors after SPS.
Gene_expression (expression) of SPS associated with stress
4) Confidence 0.01 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.55 Pain Relevance 0.12
In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS.
Gene_expression (expression) of SPS associated with stress
5) Confidence 0.01 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13

General Comments

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