INT245656

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.50
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2)
cytoplasm (Mtap2)
Anatomy Link Frequency
dentate gyrus 3
spinal cord 3
brainstem 3
cortex 1
Mtap2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 3 99.64 Very High Very High Very High
medulla 57 99.48 Very High Very High Very High
Spinal cord 90 98.64 Very High Very High Very High
Inflammation 78 83.32 Quite High
rheumatoid arthritis 3 72.72 Quite High
Pain 9 70.88 Quite High
cytokine 39 57.08 Quite High
Neuritis 2 56.08 Quite High
Multiple sclerosis 18 53.52 Quite High
Abeta 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 10 99.52 Very High Very High Very High
Gliosis 6 96.92 Very High Very High Very High
Death 66 96.44 Very High Very High Very High
INFLAMMATION 78 83.32 Quite High
Neurodegenerative Disease 20 79.32 Quite High
Rheumatoid Arthritis 3 72.72 Quite High
Pain 9 70.88 Quite High
Urological Neuroanatomy 6 69.20 Quite High
Motor Neuron Diseases 126 68.24 Quite High
Neuritis 2 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, BV treatment reduced the number of microglial cells and astrocytes, and dramatically increased the expression of MAP2 in motor-related regions of the brainstem and spinal cord in comparison with age-matched hSOD1G93A control mice.
Positive_regulation (increased) of Gene_expression (expression) of MAP2 in spinal cord associated with medulla and spinal cord
1) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 1.30 Pain Relevance 0.59
As shown in Figure 7A, Western bolt analysis revealed an increase in the expression of the neuronal cell marker MAP2 in both the brainstem and lumbar spinal cord of BV-treated symptomatic hSOD1G93A mice.
Positive_regulation (increase) of Gene_expression (expression) of MAP2 in brainstem associated with medulla and spinal cord
2) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.39 Pain Relevance 0.36
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to tended to increase MAP2 expression level in the dentate gyrus and cortex (Figures 4 and 7).
Positive_regulation (increase) of Gene_expression (expression) of MAP2 in dentate gyrus
3) Confidence 0.32 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.13 Pain Relevance 0.06
Interestingly, BV treatment reduced the number of microglial cells and astrocytes, and dramatically increased the expression of MAP2 in motor-related regions of the brainstem and spinal cord in comparison with age-matched hSOD1G93A control mice.
Positive_regulation (increased) of in brainstem Gene_expression (expression) of MAP2 in spinal cord associated with medulla and spinal cord
4) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 1.30 Pain Relevance 0.59
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to tended to increase MAP2 expression level in the dentate gyrus and cortex (Figures 4 and 7).
Positive_regulation (increase) of in cortex Gene_expression (expression) of MAP2 in dentate gyrus
5) Confidence 0.11 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.13 Pain Relevance 0.06
The majority of BrdU+ cells found in the CP, after 2 DIC, are also likely to be generated in the neocortical VZ since they express MAP2 but are GABA-negative (Figure 5K–N).
Positive_regulation (generated) of Gene_expression (express) of MAP2 associated with gaba and disseminated intravascular coagulation
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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