INT245669

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.87
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
pyramidal cells 2
pyramidal neurons 2
spikes 2
cortex 2
hippocampus 2
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 289 100.00 Very High Very High Very High
Pyramidal cell 236 100.00 Very High Very High Very High
Hippocampus 69 99.60 Very High Very High Very High
imagery 11 94.24 High High
GABAergic 33 87.72 High High
nMDA receptor antagonist 16 87.44 High High
Glutamate receptor 52 83.88 Quite High
ketamine 16 83.24 Quite High
Glutamate 4 68.08 Quite High
GABA receptor 1 61.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.04 Very High Very High Very High
Convulsion 120 98.08 Very High Very High Very High
Urological Neuroanatomy 5 96.84 Very High Very High Very High
Infection 21 96.04 Very High Very High Very High
Aging 23 95.20 Very High Very High Very High
Congenital Anomalies 9 90.16 High High
Cognitive Disorder 60 67.28 Quite High
Sprains And Strains 57 56.64 Quite High
Generalized Anxiety Disorder 8 50.80 Quite High
Anxiety Disorder 2 19.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ablation of CA3 NMDA receptors in the mature brain also generated characteristic EEG spikes with large amplitudes
Negative_regulation (Ablation) of Gene_expression (receptors) of CA3 in spikes associated with nmda receptor
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.32 Pain Relevance 0.40
Pharmacological blockade of CA3 NMDA receptors enhanced the susceptibility to kainate-induced seizure
Negative_regulation (blockade) of Gene_expression (receptors) of CA3 associated with convulsion and nmda receptor
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.54 Pain Relevance 0.35
We have evidence that inhibitory inputs to CA3 pyramidal neurons may be mainly mediated by ?
Negative_regulation (inputs) of Gene_expression (pyramidal neurons) of CA3 in pyramidal neurons associated with pyramidal cell
3) Confidence 0.33 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.13 Pain Relevance 0.39
Mean spine density on basal dendrites of CA3 pyramidal cells was also comparable (n?
Negative_regulation (dendrites) of Gene_expression (pyramidal cells) of CA3 in pyramidal cells associated with pyramidal cell
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.05 Pain Relevance 0.15
Histological features of the hippocampal CA3 region
Negative_regulation (hippocampal) of Gene_expression (region) of CA3
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.43 Pain Relevance 0.37
We found a substantial and highly significant loss of PV-interneurons in aged hippocampus (Fig. 4), with the CA2-3 region being the most affected (20% decrease for CA1, main effect of age: F(1,17)?
Negative_regulation (decrease) of Gene_expression (region) of CA2-3 in hippocampus associated with hippocampus
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.25
On the other hand, expression levels of calpastatin tended to be decreased in the cortex and CA3 of A?
Negative_regulation (decreased) of Gene_expression (cortex) of CA3 in cortex
7) Confidence 0.15 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.10 Pain Relevance 0

General Comments

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