INT245671

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.31
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
parietal cortex 4
synapses 4
dentate gyrus 3
striatum 3
pyramidal cells 2
Car1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 250 100.00 Very High Very High Very High
long-term potentiation 182 100.00 Very High Very High Very High
Pyramidal cell 49 100.00 Very High Very High Very High
depression 82 82.32 Quite High
Central nervous system 48 80.48 Quite High
Inflammation 150 78.64 Quite High
Glutamate receptor 5 73.60 Quite High
potassium channel 8 72.80 Quite High
antagonist 39 71.76 Quite High
Neuritis 4 68.84 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 261 100.00 Very High Very High Very High
Targeted Disruption 132 99.36 Very High Very High Very High
Gliosis 46 95.12 Very High Very High Very High
Death 75 86.72 High High
Anaerobic Bacterial Infections 8 82.80 Quite High
Depression 82 82.32 Quite High
Urological Neuroanatomy 13 81.96 Quite High
Nervous System Inflammation 2 79.84 Quite High
Injury 29 77.68 Quite High
Neuritis 4 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of LTP by a conventional high-frequency stimulation (HFS) protocol was significantly enhanced in the CA1 region of GluR2-cKO mice (60 minutes post-HFS, fEPSPs were potentiated to 255±19% of baseline in GluR2-cKO mice, n?
Positive_regulation (enhanced) of Gene_expression (region) of CA1 associated with long-term potentiation
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.14 Pain Relevance 0.34
These findings indicate that tbLTP in Schaffer collateral-CA1 synapses of adult Neto1-null mice is mediated primarily by NR2B-containing NMDARs.
Positive_regulation (mediated) of Gene_expression (synapses) of CA1 in synapses
2) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
Compared to control mice, the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in CA1 pyramidal neurons of EPO mice was increased, while the amplitude of sIPSCs was unchanged (Figure 4b, c).
Positive_regulation (increased) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
3) Confidence 0.25 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.55 Pain Relevance 0.49
Synaptic plasticity is significantly increased at Schaffer collateral CA1 synapses in EPO-treated mice
Positive_regulation (increased) of Gene_expression (synapses) of CA1 in synapses
4) Confidence 0.25 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.19 Pain Relevance 0.12
Responses to CA1 hippocampal tetanic stimuli in WT and Cdk5 KO mice
Positive_regulation (stimuli) of Gene_expression (hippocampal) of CA1 associated with targeted disruption
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.10 Pain Relevance 0.20
To induce LTP in hippocampal CA1 neurons, the pairing protocol involving holding CA1 neurons at +30 mV paired with 80 pulses of presynaptic stimulation at 2 Hz was used (Figure 3A).
Positive_regulation (induce) of Gene_expression (neurons) of CA1 in neurons associated with long-term potentiation
6) Confidence 0.24 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.37 Pain Relevance 0.57
(25–35)-injected mice receiving vehicle, and administration of Kihi-to resulted in significant increases in synaptophysin expression levels in CA1, the oriens and radiatum in CA3, the molecular layer in dentate gyrus (Figures 5 and 7).
Positive_regulation (increases) of Gene_expression (expression) of CA1 in molecular layer
7) Confidence 0.18 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.06 Pain Relevance 0
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of Gene_expression (expression) of CA1 in parietal cortex
8) Confidence 0.18 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
In contrast, Pittenger and colleagues used this model to overexpress dominant negative human CREB (KCREB) in either the dorsal striatum (and olfactory tubercle) [91] or dorsal hippocampus (CA1, and striatum/piriform cortex) [92], the former demonstrating a contribution of CREB to procedural learning, the latter, a somewhat subtle phenotype in relation to spatial learning and memory.
Positive_regulation (overexpress) of Neg (negative) Gene_expression (overexpress) of CA1 in striatum associated with hippocampus
9) Confidence 0.15 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.07 Pain Relevance 0.10
XE-991 application alone produced a depolarization of the membrane potential and an increase in the input resistance of CA1 pyramidal cells (1.7 ± 0.4 mV and 47 ± 5 M?
Positive_regulation (increase) of Gene_expression (pyramidal cells) of CA1 in pyramidal cells associated with pyramidal cell
10) Confidence 0.15 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.09
(D): There was, however, increased neurogenesis in the DG, CA3, and CA1 regions of the dorsal intact hippocampus in activin A-treated animals (n = 10, gray bars), whereas (FS-288)-treated animals had no effect on neurogenesis (n = 10, black bars) compared to controls (n = 10, white bars).
Positive_regulation (increased) of Gene_expression (regions) of CA1 in bars associated with hippocampus and neurodegenerative disease
11) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.43 Pain Relevance 0.11
We found that intraventricular infusion of activin A increased the number of newborn neurons in the dentate gyrus, CA3, and CA1 layers of the normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro.
Positive_regulation (increased) of Gene_expression (layers) of CA1 in dentate gyrus associated with hippocampus and gliosis
12) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.72 Pain Relevance 0.19
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of in dentate gyrus Gene_expression (expression) of CA1 in parietal cortex
13) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of in perirhinal cortex Gene_expression (expression) of CA1 in parietal cortex
14) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
In contrast, Pittenger and colleagues used this model to overexpress dominant negative human CREB (KCREB) in either the dorsal striatum (and olfactory tubercle) [91] or dorsal hippocampus (CA1, and striatum/piriform cortex) [92], the former demonstrating a contribution of CREB to procedural learning, the latter, a somewhat subtle phenotype in relation to spatial learning and memory.
Positive_regulation (overexpress) of in piriform cortex Neg (negative) Gene_expression (overexpress) of CA1 in striatum associated with hippocampus
15) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.07 Pain Relevance 0.10

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