INT24569

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 21.82
Pain Relevance 21.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nociceptors 3
neck 1
sciatic nerve 1
paw 1
Knee 1
Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 886 100.00 Very High Very High Very High
Neuropathic pain 373 100.00 Very High Very High Very High
IPN 157 100.00 Very High Very High Very High
Sciatic nerve 47 99.84 Very High Very High Very High
depression 12 99.80 Very High Very High Very High
Angina 4 99.78 Very High Very High Very High
Osteoarthritis 10 99.68 Very High Very High Very High
nociceptor 644 99.66 Very High Very High Very High
Endocannabinoid 77 99.58 Very High Very High Very High
Opioid 34 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 973 100.00 Very High Very High Very High
Neuropathic Pain 504 100.00 Very High Very High Very High
Inflammatory Pain 157 100.00 Very High Very High Very High
Weight Loss 6 100.00 Very High Very High Very High
Depression 14 99.80 Very High Very High Very High
Cv General 3 Under Development 4 99.78 Very High Very High Very High
Nervous System Injury 151 99.74 Very High Very High Very High
Osteoarthritis 9 99.68 Very High Very High Very High
Neck Pain 3 99.60 Very High Very High Very High
Depressive Disorder 2 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have shown that felbamate can decrease sEPSC frequency by blocking presynaptic facilitatory NMDA autoreceptors (Yang et al., 2007).
Negative_regulation (blocking) of auto
1) Confidence 0.41 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.33
During the animals’ recovery from the noxious insult and the regeneration of wellbeing, the motivation to burrow will prevail over pain and impairment.
Negative_regulation (prevail) of pain associated with pain
2) Confidence 0.34 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.69 Pain Relevance 0.65
Knee replacement is the most effective treatment in reducing pain due to osteoarthritis, and about 90% report satisfactory pain relief [26].
Negative_regulation (reducing) of pain in Knee associated with pain and osteoarthritis
3) Confidence 0.29 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.73 Pain Relevance 1.10
These results suggest that inflammatory pain is impaired in both E-CKO and L-CKO mice [14].
Negative_regulation (impaired) of pain associated with ipn
4) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.18 Pain Relevance 1.30
If extrinsic PEEP is to be used, then careful bedside observation with a clear understanding of how the benefits (reductions in auto-PEEP) and adverse effects (worsening gas-trapping) would manifest is mandatory.


Negative_regulation (reductions) of auto-PEEP
5) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1414026 Disease Relevance 0.61 Pain Relevance 0
Thus, the selective loss of program A activity in L-CKO mice leads to a selective defect in inflammatory pain, and the retention of program B activity is sufficient to establish heat pain and neuropathic pain.


Negative_regulation (defect) of pain associated with pain, ipn and neuropathic pain
6) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.12 Pain Relevance 1.28
Second, a selective defect in program A in L-CKO mice led to impaired inflammatory pain (CFA-induced mechanical allodynia and heat hyperalgesia), whereas the retention of program B activity in these mice is sufficient to establish neuropathic pain (SNI-induced mechanical allodynia).
Negative_regulation (impaired) of pain associated with hyperalgesia, allodynia, ipn and neuropathic pain
7) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.12 Pain Relevance 1.76
Conditional mutation of Runx1 at perinatal stages leads to preferential impairment of Runx1-persistent nociceptors and a selective defect in inflammatory pain.
Negative_regulation (defect) of pain in nociceptors associated with ipn and nociceptor
8) Confidence 0.06 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2919460 Disease Relevance 0.71 Pain Relevance 1.35
Interestingly, behavioral analyses showed that preferential defect in Runx1-persistent nociceptors in these late knockouts led to a selective impairment of inflammatory pain without affecting neuropathic pain.
Negative_regulation (impairment) of pain in nociceptors associated with ipn, nociceptor and neuropathic pain
9) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.15 Pain Relevance 1.37
Interestingly, neuropathic pain using the SNI model was severely impaired in Tau-Runx1F;Nav1.8Cre mice, as shown by a substantial increase in the paw withdrawal threshold in these mice compared to that in Tau-Runx1F control littermates (Fig. 5C, ANOVA, p < 0.001).
Negative_regulation (impaired) of pain in paw associated with neuropathic pain and withdrawal
10) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.89 Pain Relevance 1.06
However, when we used Nav1.8Cre mice (made in the Kuner lab) to drive Runx1 expression, neuropathic pain was impaired.
Negative_regulation (impaired) of pain associated with neuropathic pain
11) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.97 Pain Relevance 0.91
A selective deficit of inflammatory pain in L-CKO mice
Negative_regulation (deficit) of pain associated with ipn
12) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.40 Pain Relevance 0.29
The additive effects of disturbances of both the opioid and endocannabinoid-mediated endogenous inhibition of pain probably contribute to the therapeutic difficulties in achieving sufficient pain relief, particularly for intractable clinical manifestations such as cold and tactile allodynia.
Negative_regulation (inhibition) of pain associated with brush evoked pain, pain, endocannabinoid and opioid
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.85 Pain Relevance 0.99
In relation to thermal QST, Johnston et al., [34] found that office workers with mild neck pain and disability had decreased heat pain thresholds and were more sensitive to cold pain than controls or office workers without pain.
Negative_regulation (decreased) of pain in neck associated with pain, quantitative sensory testing and neck pain
14) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.29 Pain Relevance 1.41
Clinical severity of all symptoms decreased, except for involuntary weight loss and pain in group II.
Neg (except) Negative_regulation (loss) of pain associated with pain and weight loss
15) Confidence 0.03 Published 2008 Journal Dig Dis Sci Section Abstract Doc Link PMC2467533 Disease Relevance 0.41 Pain Relevance 0.10
Total pain increased in four patients (all in group II), was stable in three (one in group I and two in group II), while the remaining patients had a decrease in total pain.


Negative_regulation (decrease) of pain associated with pain
16) Confidence 0.03 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2467533 Disease Relevance 1.10 Pain Relevance 0.39
In both groups, the clinical severity of all symptoms decreased, except for involuntary weight loss and pain in group II.
Neg (except) Negative_regulation (loss) of pain associated with pain and weight loss
17) Confidence 0.03 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2467533 Disease Relevance 0.90 Pain Relevance 0.38
We show that R-flurbiprofen reduces glutamate release in the dorsal horn of the spinal cord evoked by sciatic nerve injury and thereby alleviates pain in sciatic nerve injury models of neuropathic pain in rats and mice.
Negative_regulation (alleviates) of pain in sciatic nerve associated with pain, glutamate, nervous system injury, neuropathic pain, dorsal horn, sciatic nerve and spinal cord
18) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2869361 Disease Relevance 0.65 Pain Relevance 0.84
R-flurbiprofen reduces neuropathic pain-like behavior
Negative_regulation (reduces) of pain associated with neuropathic pain
19) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.27 Pain Relevance 0.57
Studies using genetically modified mice have proposed a large number of candidate ‘pain genes’[6].
Negative_regulation (number) of pain associated with pain
20) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.37 Pain Relevance 0.49

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