INT245736

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 7.65
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
Anatomy Link Frequency
forebrain 2
nucleus 2
intervertebral discs 1
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Facet joint 15 98.52 Very High Very High Very High
adenocard 8 97.88 Very High Very High Very High
Neurobehavioral 132 96.40 Very High Very High Very High
fibrosis 3 91.84 High High
Arthritis 3 79.04 Quite High
spinal stenosis 6 77.52 Quite High
backache 50 73.52 Quite High
Pain 67 64.32 Quite High
Osteoarthritis 8 59.84 Quite High
rheumatoid arthritis 11 57.92 Quite High
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 324 100.00 Very High Very High Very High
Schizophrenia 316 100.00 Very High Very High Very High
Disease 300 100.00 Very High Very High Very High
Osteophyte 11 97.48 Very High Very High Very High
Keloid Scars 3 96.16 Very High Very High Very High
Osteoporosis 14 93.04 High High
Fibrosis 3 91.84 High High
Osteoarthritis 11 86.08 High High
Psychosis 684 80.04 Quite High
Arthritis 3 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DISC1 protein is expressed in multiple intracellular compartments, including the nucleus, centrosome, mitochondria, microtubule fractions, actin cytoskeletal fractions, and postsynaptic densities, Among the possible functions of DISC1, mediation of centro-some-dynein cascade and cyclic adenosine monophosphate (cAMP) signaling have been described.
Gene_expression (expressed) of DISC1 in nucleus associated with adenocard
1) Confidence 0.61 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646642 Disease Relevance 0.36 Pain Relevance 0.15
DISC1 protein is expressed in multiple intracellular compartments, including the nucleus, centrosome, mitochondria, microtubule fractions, actin cytoskeletal fractions, and postsynaptic densities, Among the possible functions of DISC1, mediation of centro-some-dynein cascade and cyclic adenosine monophosphate (cAMP) signaling have been described.
Gene_expression (expressed) of DISC1 in nucleus associated with adenocard
2) Confidence 0.53 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646642 Disease Relevance 0.52 Pain Relevance 0.17
DISC1 (an acronym for Disrupted-In-Schizophrenia-1) appears to play a role in neurodevelopment and is preferentially expressed in the forebrain.
Gene_expression (expressed) of DISC1 in forebrain associated with schizophrenia
3) Confidence 0.48 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646642 Disease Relevance 0.40 Pain Relevance 0.14
DISC1 (an acronym for Disrupted-In-Schizophrenia-1) appears to play a role in neurodevelopment and is preferentially expressed in the forebrain.
Gene_expression (expressed) of Disrupted-In-Schizophrenia-1 in forebrain associated with schizophrenia
4) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646642 Disease Relevance 0.40 Pain Relevance 0.14
These devices are modular systems and are intended to be used as intervertebral dynamic disc spacers in the lumbar vertebral region at the L3/L4 (ProDisc-L only), L4/L5 and L5/S1 levels.
Gene_expression (levels) of ProDisc
5) Confidence 0.31 Published 2010 Journal BMC Surg Section Body Doc Link PMC2858130 Disease Relevance 0.77 Pain Relevance 0.25
decreased disc height of > 2 mm as compared to the adjacent level.

?

Gene_expression (height) of disc
6) Confidence 0.27 Published 2010 Journal BMC Surg Section Body Doc Link PMC2858130 Disease Relevance 0.70 Pain Relevance 0.34
The first three subjects at each investigational site will receive the Activ-L Disc and will be not be randomized, these patients will be outside of the trial.
Gene_expression (receive) of Disc
7) Confidence 0.27 Published 2010 Journal BMC Surg Section Body Doc Link PMC2858130 Disease Relevance 0 Pain Relevance 0
Approaches in studying genetic traits of lumbar disc herniation
Gene_expression (herniation) of lumbar disc
8) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.58 Pain Relevance 0
Videman et al 37 and Kawaguchi et al 38 reported that subjects with the tt or Tt allele of the vitamin-D receptor gene were more frequently associated with multilevel and severe disc degeneration and disc herniation than ones with the TT allele.
Gene_expression (herniation) of disc associated with intervertebral disk degeneration
9) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.77 Pain Relevance 0
On the whole, genetic study with relation to lumbar disc disease would offer new evidence for prevention and cure of lumbar disc disease.



Gene_expression (disease) of lumbar disc associated with disease
10) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.34 Pain Relevance 0
Candidate-gene polymorphisms associated with disc degeneration
Gene_expression (degeneration) of disc associated with intervertebral disk degeneration
11) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.42 Pain Relevance 0
Accordingly, the allelic variation of COL9A2 that is associated with lumbar disc disease is dependent on race and nationality.

4.1.2 COL9A3

Gene_expression (disease) of lumbar disc associated with disease
12) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.68 Pain Relevance 0.06
Category 2 consists of genes that produce the degradation enzymes of the disc matrix, for example, the matrix metalloprotease-3 gene.
Gene_expression (produce) of disc
13) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.51 Pain Relevance 0
Wang et al 26 reported that type IV collagen occurring in the disc of adolescents is the result of early cellular reaction to harmful stimuli, and this can serve as a biological marker for early degeneration of human lumbar intervertebral discs.
Gene_expression (occurring) of disc in intervertebral discs
14) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.46 Pain Relevance 0
A substantial genetic influence on disc degeneration was found.
Gene_expression (degeneration) of disc associated with intervertebral disk degeneration
15) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.72 Pain Relevance 0.07

General Comments

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