INT245742

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 79.36 Quite High
cytokine 2 17.36 Low Low
backache 8 12.00 Low Low
Pain 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 78 100.00 Very High Very High Very High
Disease 66 99.96 Very High Very High Very High
Targeted Disruption 2 98.66 Very High Very High Very High
INFLAMMATION 6 79.36 Quite High
Osteoporosis 2 62.44 Quite High
Low Back Pain 8 12.00 Low Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Spinal Osteophytosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice expressing mutant alpha 1(IX) collagen were reported to have accelerated disc degeneration 12.
Positive_regulation (accelerated) of disc associated with intervertebral disk degeneration and targeted disruption
1) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.49 Pain Relevance 0
It is likely genetic marker of degenerative disc disease.

4.6 Matrix metalloprotease-3

Spec (likely) Positive_regulation (degenerative) of disc associated with disease
2) Confidence 0.09 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

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