INT245744

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.92
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
Anatomy Link Frequency
Spinal 1
intervertebral disc 1
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 28 83.92 Quite High
Sciatica 7 68.00 Quite High
rheumatoid arthritis 7 57.12 Quite High
Osteoarthritis 7 55.92 Quite High
Inflammation 21 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 273 100.00 Very High Very High Very High
Spinal Osteophytosis 14 99.14 Very High Very High Very High
Scheuermann's Disease 7 94.96 High High
Disease 231 92.80 High High
Aging 7 90.72 High High
Osteoporosis 7 90.00 High High
Nicotine Addiction 21 88.72 High High
Obesity 14 87.16 High High
Low Back Pain 28 83.92 Quite High
Nerve Root Compression 7 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Category 2 consists of genes that produce the degradation enzymes of the disc matrix, for example, the matrix metalloprotease-3 gene.
Protein_catabolism (degradation) of disc
1) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.51 Pain Relevance 0
Mutation and polymorphism of Sox9 gene and association with intervertebral disc degeneration remain to be studied.

4.5 Vitamin D receptor

Protein_catabolism (degeneration) of disc in intervertebral disc associated with intervertebral disk degeneration
2) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.47 Pain Relevance 0
Solovieva et al 22 had further researched the relation of gene-environment interaction, and found that incidence rate of lumbar disc degeneration was increased for interactions of the mutation of COL9A3 gene with persistent load on disc.
Protein_catabolism (degeneration) of lumbar disc associated with intervertebral disk degeneration
3) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 1.03 Pain Relevance 0.06
Spinal osteophytosis and disc narrowing are closely related to disc degeneration.
Protein_catabolism (degeneration) of disc in Spinal associated with intervertebral disk degeneration and spinal osteophytosis
4) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.83 Pain Relevance 0
Videman et al 37 and Kawaguchi et al 38 reported that subjects with the tt or Tt allele of the vitamin-D receptor gene were more frequently associated with multilevel and severe disc degeneration and disc herniation than ones with the TT allele.
Protein_catabolism (degeneration) of disc associated with intervertebral disk degeneration
5) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.77 Pain Relevance 0
In recent years, however, a dramatic advance has been made in our understanding of genetic influences on the risk for disc degeneration, thus changing our traditional views.
Protein_catabolism (degeneration) of disc associated with intervertebral disk degeneration
6) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.60 Pain Relevance 0.15
Pluijm et al 23 and Tilkeridis et al 24 reported that the risk of disc degeneration for people with the TT genotype was higher than people with the GG or GT genotype.
Protein_catabolism (degeneration) of disc associated with intervertebral disk degeneration
7) Confidence 0.16 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.71 Pain Relevance 0

General Comments

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