INT245748

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 5.21
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
Anatomy Link Frequency
intervertebral disc 2
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 95.76 Very High Very High Very High
Sciatica 8 94.28 High High
Inflammation 24 93.20 High High
backache 32 92.80 High High
COX2 8 86.96 High High
imagery 8 82.56 Quite High
cytokine 8 67.52 Quite High
Osteoarthritis 8 42.88 Quite Low
rheumatoid arthritis 8 40.96 Quite Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 312 100.00 Very High Very High Very High
Disease 264 99.96 Very High Very High Very High
Pain 16 95.76 Very High Very High Very High
Nerve Root Compression 8 94.28 High High
INFLAMMATION 24 93.20 High High
Spinal Osteophytosis 16 93.04 High High
Low Back Pain 32 92.80 High High
Nicotine Addiction 24 82.84 Quite High
Aging 8 47.44 Quite Low
Osteoarthritis 8 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seki et al 17 reported Trp2 was common in Japanese, and no association with lumbar disc degeneration was apparent.
lumbar disc Neg (no) Binding (association) of associated with intervertebral disk degeneration
1) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.48 Pain Relevance 0
Furthermore, Videman et al 40 found two intragenic polymorphisms of the vitamin D receptor gene associated with disc degeneration.
disc Binding (degeneration) of associated with intervertebral disk degeneration
2) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.74 Pain Relevance 0
Hence both of them may be taken as molecular markers of disc degeneration.
disc Binding (degeneration) of associated with intervertebral disk degeneration
3) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.41 Pain Relevance 0
To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease.

4.4 Sox9

disc Binding (intervertebral) of in intervertebral disc associated with disease
4) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
Now, many researchers unanimously agree that lumbar disc herniation appears to be similar to other complex diseases, whose etiology has both environmental and hereditary influence, each with a part of contribution and relative risk.
lumbar disc Binding (herniation) of associated with disease
5) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.77 Pain Relevance 0.16
Genetic factors, in particular, may be largely responsible for the degeneration as well as herniation of intervertebral disc 3.
disc Binding (herniation) of in intervertebral disc
6) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.63 Pain Relevance 0.16
At present, the study of allele of COL9A2 is more extensive than the other genes associated with lumbar disc disease.
lumbar disc Binding (associated) of associated with disease
7) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.75 Pain Relevance 0.23
gene associates with Lumbar disc disease in Chinese.
Lumbar disc Binding (associates) of associated with disease
8) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 1.02 Pain Relevance 0.53

General Comments

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