INT245757

Context Info Confidence 0.62 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.80 Pain Relevance 0

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

Anatomy Link Frequency intervertebral disc 2 SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 23.24 Inflammation 9 5.00 backache 8 5.00 Osteoarthritis 7 5.00 Pain 5 5.00 cytokine 3 5.00 metalloproteinase 3 5.00 Arthritis 3 5.00 Bioavailability 2 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Disease 69 100.00 Intervertebral Disk Degeneration 78 94.60 Overdose 1 34.64 Hypertrophy 2 33.92 Obesity 7 22.28 Apoptosis 11 5.00 Osteoarthritis 11 5.00 Low Back Pain 8 5.00 INFLAMMATION 8 5.00 Nicotine Addiction 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease. 4.4 Sox9

Localization (4.4) of Sox9 in intervertebral disc associated with disease

1) Confidence 0.62 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0

To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease. 4.4 Sox9

Localization (disease.) of Sox9 in intervertebral disc associated with disease

2) Confidence 0.62 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0

, product size, 562 bp; SOX9, sense (5?

Localization (sense) of SOX9

3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2579486 Disease Relevance 0 Pain Relevance 0

Aggrecan gene expression in day-7 MMC followed a similar pattern to that observed for SOX-9, with the highest expression relative to control MMC occurring at 20 ?

Localization (observed) of SOX-9

4) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0

General Comments

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