INT245759

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.85
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
Anatomy Link Frequency
intervertebral disc 3
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 79.36 Quite High
cytokine 7 17.36 Low Low
Osteoarthritis 7 12.80 Low Low
backache 28 12.00 Low Low
rheumatoid arthritis 7 10.88 Low Low
Pain 14 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Sciatica 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 231 100.00 Very High Very High Very High
Intervertebral Disk Degeneration 273 94.80 High High
INFLAMMATION 21 79.36 Quite High
Osteoporosis 7 69.20 Quite High
Targeted Disruption 7 68.84 Quite High
Spinal Osteophytosis 14 58.84 Quite High
Nicotine Addiction 21 30.40 Quite Low
Obesity 14 22.48 Low Low
Osteophyte 7 21.68 Low Low
Aging 7 13.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely genetic marker of degenerative disc disease.

4.6 Matrix metalloprotease-3

Localization (marker) of disc associated with disease
1) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.35 Pain Relevance 0.04
There are four major categories of candidate-genes related to lumbar disc disease (Fig. 1).
Localization (disease) of lumbar disc associated with disease
2) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.49 Pain Relevance 0
All members who had inherited the allele in these families had intervertebral disc disease 13.
Localization (disease) of disc in intervertebral disc associated with disease
3) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.42 Pain Relevance 0
Like many hydrophobic amino acids, Trp may disrupt the collagen triple helix, as well as interfere with the interaction between collagens IX and II or prevent the action of lysyl oxidase, which catalyzes cross-link formation, and thus cause disc disease.
Localization (disease) of disc associated with disease
4) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease.

4.4 Sox9

Localization (disease.) of disc in intervertebral disc associated with disease
5) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease.

4.4 Sox9

Localization (4.4) of disc in intervertebral disc associated with disease
6) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
Cheung et al 41 had further confirmed that the t allele of vitamin D receptor Taq I was associated with a high risk of degenerative disc disease and disc bulge developing, especially in individuals younger than 40 years.
Localization (disease) of disc associated with disease
7) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0

General Comments

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