INT245762

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 1
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2 23.68 Low Low
Osteoarthritis 2 22.48 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
backache 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 3 99.12 Very High Very High Very High
Uterine Fibroids 120 98.64 Very High Very High Very High
Intervertebral Disk Degeneration 78 92.56 High High
Sprains And Strains 78 83.44 Quite High
Disease 72 80.00 Quite High
Obesity 4 79.04 Quite High
Scheuermann's Disease 2 61.52 Quite High
Rheumatoid Arthritis 26 49.68 Quite Low
Targeted Disruption 5 34.96 Quite Low
Chondrodysplasia 2 24.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the intronic polymorphism of the Sp1 binding site of COLIA1 may affect the transcription of collagen I.
Transcription (transcription) of collagen
1) Confidence 0.09 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.63 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Transcription (expression) of collagen
2) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.77 Pain Relevance 0
Compared with knitted scaffolds alone after 14 days of hMSC culture, the knitted-sponge scaffolds showed significantly higher biological responses with nearly every evaluation method (p < 0.05), including cellular proliferation, GAG production, viable cell density, mRNA expression of collagen types I and III, and tenascin-C, and collagen-based matrix production, confirming the positive benefit of the microporous silk sponge.
Transcription (expression) of collagen associated with hyperplasia
3) Confidence 0.06 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.10 Pain Relevance 0
Compared with knitted scaffolds alone after 14 days of hMSC culture, the knitted-sponge scaffolds showed significantly higher biological responses with nearly every evaluation method (p < 0.05), including cellular proliferation, GAG production, viable cell density, mRNA expression of collagen types I and III, and tenascin-C, and collagen-based matrix production, confirming the positive benefit of the microporous silk sponge.
Transcription (expression) of collagen associated with hyperplasia
4) Confidence 0.06 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.10 Pain Relevance 0
The most striking finding was that the mRNA expression of collagen type I, collagen type III, and tenascin-C in mechanically stimulated gels were all significantly upregulated compared to static controls and approached native T/L expression, and that bone and cartilage markers were not upregulated.
Transcription (expression) of collagen in cartilage
5) Confidence 0.06 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.43 Pain Relevance 0
The mRNA expression was increased for collagen genes COL1A1 (2·72 ± 0·55-fold; P < 0·05) and COL4A1 (2·95 ± 0·37-fold; P < 0·05) in leiomyoma cells as compared to myometrial cells prior to treatment (Fig. 3).
Transcription (expression) of collagen associated with uterine fibroids
6) Confidence 0.04 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.80 Pain Relevance 0

General Comments

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