INT245763

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.68
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
Anatomy Link Frequency
NMU 1
nucleus pulposus 1
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 93.48 High High
headache 2 73.68 Quite High
cytokine 7 53.96 Quite High
Inflammatory response 17 21.52 Low Low
chemokine 1 5.28 Low Low
Osteoarthritis 30 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arachnoid Cysts 51 98.40 Very High Very High Very High
INFLAMMATION 111 93.48 High High
Disease 44 89.28 High High
Chromosome Duplication 1 88.60 High High
Cyst 11 82.60 Quite High
Stress 9 76.24 Quite High
Dizziness 2 74.12 Quite High
Headache 2 73.68 Quite High
Intervertebral Disk Degeneration 39 68.84 Quite High
Aging 2 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chondrogenic differentiation and the SOX9 dependency of aggrecan and collagen expression may also be differentially modulated by these transcriptional cofactors under different tonicities.
Spec (may) Regulation (modulated) of SOX9
1) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0
Expression and regulation of Sox9 gene also were seen at the nucleus pulposus cells 34.
Regulation (regulation) of Sox9 in nucleus pulposus
2) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.29 Pain Relevance 0
Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.
Regulation (regulated) of SOX9 in NMU associated with arachnoid cysts
3) Confidence 0.21 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.97 Pain Relevance 0.07
However, there are several time lag regulations in IL8 and its regulators, such as SOX9, MEF2A, NFIL3, ELK1, FOXF1, FOXD1, GATA2, FOXI1, REL and RELA.
Regulation (regulations) of SOX9
4) Confidence 0.19 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.28 Pain Relevance 0.14

General Comments

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