INT245763

Context Info Confidence 0.43 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.68 Pain Relevance 0.21

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

Anatomy Link Frequency NMU 1 nucleus pulposus 1 SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 89 93.48 headache 2 73.68 cytokine 7 53.96 Inflammatory response 17 21.52 chemokine 1 5.28 Osteoarthritis 30 5.00 backache 4 5.00 Inflammatory stimuli 4 5.00 Pain 3 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Arachnoid Cysts 51 98.40 INFLAMMATION 111 93.48 Disease 44 89.28 Chromosome Duplication 1 88.60 Cyst 11 82.60 Stress 9 76.24 Dizziness 2 74.12 Headache 2 73.68 Intervertebral Disk Degeneration 39 68.84 Aging 2 54.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chondrogenic differentiation and the SOX9 dependency of aggrecan and collagen expression may also be differentially modulated by these transcriptional cofactors under different tonicities.

Spec (may) Regulation (modulated) of SOX9

1) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0

Expression and regulation of Sox9 gene also were seen at the nucleus pulposus cells 34.

Regulation (regulation) of Sox9 in nucleus pulposus

2) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.29 Pain Relevance 0

Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.

Regulation (regulated) of SOX9 in NMU associated with arachnoid cysts

3) Confidence 0.21 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.97 Pain Relevance 0.07

However, there are several time lag regulations in IL8 and its regulators, such as SOX9, MEF2A, NFIL3, ELK1, FOXF1, FOXD1, GATA2, FOXI1, REL and RELA.

Regulation (regulations) of SOX9

4) Confidence 0.19 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.28 Pain Relevance 0.14

General Comments

This test has worked.