INT245764

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DISC1) cytoplasm (DISC1)
Anatomy Link Frequency
intervertebral disc 1
DISC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 88.76 High High
Inflammation 6 85.96 High High
Pain 4 76.76 Quite High
backache 8 73.80 Quite High
imagery 2 63.56 Quite High
cytokine 2 48.52 Quite Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 78 100.00 Very High Very High Very High
Disease 66 99.24 Very High Very High Very High
INFLAMMATION 6 85.96 High High
Pain 4 76.76 Quite High
Low Back Pain 8 73.80 Quite High
Spinal Osteophytosis 4 19.36 Low Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Scheuermann's Disease 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kawaguchi et al speculated that this polymorphism in the vitamin-D receptor gene might alter the structural characteristics of the matrix in the intervertebral disc 38.
Spec (might) Regulation (alter) of disc in intervertebral disc
1) Confidence 0.08 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.31 Pain Relevance 0
Lumbar disc degeneration is not only regulated by multiple genes and some environmental factors, but also gene-gene interactions and gene-environment interactions may also exist.
Regulation (regulated) of Lumbar disc associated with intervertebral disk degeneration
2) Confidence 0.05 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.92 Pain Relevance 0.38

General Comments

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