INT245796

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.76
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
blood vessels 2
vessels 1
bile 1
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 64 99.26 Very High Very High Very High
ischemia 24 98.00 Very High Very High Very High
corticosteroid 7 90.48 High High
cytokine 4 81.80 Quite High
Inflammation 9 33.44 Quite Low
Central nervous system 16 13.88 Low Low
anesthesia 11 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 281 99.08 Very High Very High Very High
Brain Hemorrhage 8 98.60 Very High Very High Very High
Targeted Disruption 11 87.44 High High
Increased Venous Pressure Under Development 7 85.48 High High
Diabetic Macular Edema 54 84.04 Quite High
Apoptosis 12 83.44 Quite High
Retinal Diseases 5 77.44 Quite High
Hypoxia 18 68.76 Quite High
Infection 7 68.76 Quite High
Metastasis 3 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, Raimondi et al. [23] reported that unconjugated bile acids increased TJ permeability via occludin dephosphorylation, but not via any reduction in TJ protein expression, in Caco-2 cells.
Phosphorylation (dephosphorylation) of occludin in bile associated with bile
1) Confidence 0.33 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0.37
There are several reports indicating that the phosphorylation of occludin at tyrosine residues (Tyr-398 and Tyr-402) decreases the interaction of this protein with ZO-1, ZO-2 and ZO-3, thus enhancing the permeability of the blood vessels [36,37].
Phosphorylation (phosphorylation) of occludin in blood vessels
2) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.08 Pain Relevance 0.04
Occludin can also become phosphorylated on serine and threonine (ser/thre) residues, but the effect of this phosphorylation event is distinct from that of tyrosine residue.
Phosphorylation (phosphorylated) of Occludin
3) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.09 Pain Relevance 0.05
In fact, elevated ser/thre phosphorylation of occludin promotes the assembly of the tight junctions, resulting in a reduction in permeable vessels [39].
Phosphorylation (phosphorylation) of occludin in vessels
4) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.09 Pain Relevance 0.04
Increased phosphorylation of occludin at tyrosine residue is shown in a focal cerebral ischemia model of the BBB disruption, further supporting a role for tight junction protein phosphorylation in regulating the permeability of blood vessels [38].
Phosphorylation (phosphorylation) of occludin in blood vessels associated with brain hemorrhage and ischemia
5) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.10 Pain Relevance 0.05
A concomitant decrease in occludin phosphorylation, potentially countering the effects of VEGF-A, has also been noted (35).
Phosphorylation (phosphorylation) of occludin
6) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.43 Pain Relevance 0.21
The retinal expression of VEGF, PEDF, phosporylation of p42/p44 MAPK, and occludin were analyzed by the Wilcoxon signed-rank test.
Phosphorylation (phosporylation) of occludin
7) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.38 Pain Relevance 0
VEGF stimulates phosphorylation and redistribution of occludin [19], which is subsequently endocytosed and degraded [47,48].
Phosphorylation (phosphorylation) of occludin
8) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.77 Pain Relevance 0
Furthermore, VEGF affects the tight junction protein occludin, inducing occludin phosphorylation [19] and redistribution [20]; resultant occludin reduction is associated with BRB breakdown in diabetes [21].
Phosphorylation (phosphorylation) of occludin associated with diabetes mellitus
9) Confidence 0.17 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.81 Pain Relevance 0

General Comments

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