INT245803

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.02
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r2b) signal transduction (Ppp2r2b) mitochondrion (Ppp2r2b)
cytoskeleton (Ppp2r2b) cytoplasm (Ppp2r2b)
Anatomy Link Frequency
retina 1
Ppp2r2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 21 91.80 High High
anesthesia 7 81.44 Quite High
ketamine 3 40.28 Quite Low
isoflurane 3 38.64 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 237 99.72 Very High Very High Very High
Leukostasis 3 99.40 Very High Very High Very High
Diabetic Macular Edema 74 98.24 Very High Very High Very High
Age-related Macular Degeneration 27 88.64 High High
Apoptosis 5 85.08 High High
Metastasis 1 82.04 Quite High
Cancer 1 81.16 Quite High
Injury 7 80.76 Quite High
Cataract 9 73.60 Quite High
Fibromyalgia 6 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IVTA has been shown to inhibit VEGF-induced breakdown of the BRB in rabbit and leukostasis in rat models of DR (16,17).
Protein_catabolism (breakdown) of BRB associated with diabetic macular edema and leukostasis
1) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 1.51 Pain Relevance 0.05
In our study, the direct relationship between the expression of FLK-1 and the vascular permeability/breakdown of the BRB was further investigated in the diabetic retina.
Protein_catabolism (breakdown) of BRB in retina associated with diabetes mellitus
2) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.60 Pain Relevance 0
To quantitate BRB breakdown (immunochemical analysis of albumin leakage), rats were killed without perfusion.
Protein_catabolism (breakdown) of BRB
3) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.05 Pain Relevance 0.08
BRB breakdown may be due to disassembly of unique proteins that constitute the functional vascular endothelial tight junction [16-18].
Protein_catabolism (breakdown) of BRB
4) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.86 Pain Relevance 0

General Comments

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